Shanghai Hengrui Pharmaceutical Co., Ltd.

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Jiangsu Hengrui Medicine Company Ltd.

Jiangsu Hansoh Pharmaceuticals Co., Ltd.

Fuqiang Zhao

Peng Cho Tang

Takuya Matsumoto

Zhigang Lin

Wei Zhang

Fanglong Yang

Yidong Su

Hejun Lü

Guangyuan Shen

Dongliang Guan

Jianghong Fu

Jialiang Yang

Lei Zhang

Ying Zhou

Hejun Lu

Yali Li

Pengcho Tang

Pingyan Bie

Guangtao Qian

Minggang Ju

Jianhong Fu

The invention provides derivatives of azabicyclo alkane having formula (ID), and the method for making them, wherein each substitute in formula (ID) is same as defined in the description. 

Dicycloazaalkane derivatives, preparation processes and medical uses thereof

The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, especially as protein kinase inhibitors, wherein each substituent in formula (I) is same as defined in the description. 

Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof

Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification. 

Dicycloazaalkane derivates, preparation processes and medical uses thereof

Pyrrolo[3,2-c]pyridine-4-one-2-indolinone compounds, especially 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1H-pyrrol[3,2-c]pyridine-4(5H)-one compounds. Their preparation and pharmaceutical composition, and pharmaceutical use as protein kinase inhibitors. 

2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1H-pyrrol[3,2-C]pyridine-4(5H)-one compounds and use as protein kinase inhibitors

Derivatives of azabicyclo octane presented by formula (I), the method of making them, and the compositions containing the same and the uses thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV), wherein the substitutes in formula (I) have the same meanings as what is mentioned in the descriptions.

Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV

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Shanghai, China

Fuqiang Zhao