University of California

Fuqiang Wang

Chengtian Shen

David Lee Van Vranken

Stanley Chungsing Hiew

Haoping Liu

Kevin Andre Scott

Shelley Ren-An Lane

Ilandari Dewage Udara Anulal Premachandra

Aaron David Mood

Small molecules comprised of spiroindolinone analogues are provided. Some spiroindolinones are provided with a particular relative stereochemistry in which the indolone carbonyl and all three hydrogens are on the same face of the central pyrrolidine ring. A stereoselective method of synthesis is provided for making some of the spiroindolinones described above. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, fungal infections. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

Spiroindolinones and therapeutic uses thereof

Growing community of inventors

Irvine, CA, United States of America

Fuqiang Wang