Astellas Pharma Gmbh

Kotobuki Pharmaceutical Co Ltd

Kotobuki Pharmaceuticals Co., Ltd.

Fumiyoshi Iwasaki

Takeshi Murakami

Yoshinori Kobayashi

Atsushi Noda

Hiroshi Tomiyama

Takashi Sugane

Ryota Shiraki

Kazuhiro Ikegai

Masakazu Imamura

Eiji Kurosaki

Kayoko Kitta

Shigeru Yoshida

Kenji Negoro

Yasuhiro Yonetoku

Takatoshi Soga

Norio Asai

Kei Ohnuki

Toshio Kurosaki

Ryota Astellas Pharma Inc Shiraki

The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via &#x2014;X&#x2014; and A ring is directly bonded to the glucose residue, and it is usable as a Na-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.

C-glycoside derivatives and salts thereof

A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided. It was found that an oxadiazolidinedione compound which is characterized by the possession of a benzyl or the like substituent binding to the cyclic group via a linker at the 2-position of the oxadiazolidinedione ring, or a pharmaceutically acceptable salt thereof, has excellent GPR40 agonist action. In addition, since the oxadiazolidinedione compound of the present invention showed excellent insulin secretion promoting action and blood glucose level-lowering action, it is useful as an insulin secretion promoter or an agent for preventing/treating diabetes.

Oxadiazolidinedione compound

Growing community of inventors

Tokyo, Japan

Fumiyoshi Iwasaki