Taisho Pharmaceutical Co., Ltd.

Toyama Chemical Co., Ltd.

Fujifilm Toyama Chemical Co., Ltd.

Fumito Uneuchi

Tetsuya Yabuuchi

Shoichi Kuroda

Yusuke Oka

Masato Takahashi

Hiroki Urabe

Hajime Takashima

Hironori Kotsubo

Muneo Shoji

Yasuko Kawaguchi

Risa Tsuruta

Yoichiro Suga

Yuji Ito

Hiroshi Ohta

Tsuyoshi Shibata

Naoya Ono

Yoshinori Sekiguchi

Hajime Asanuma

Takahiro Oi

Tetsuo Takayama

Yasunobu Ushiki

Madoka Kawamura

Kenichi Kawabe

Takeshi Koami

Daisuke Wakasugi

Hideaki Tabuse

Yuki Kobayashi

Rie Nishikawa

Eiji Munetomo

Sumi Chonan

Kanako Hatanaka

Yuko Uehara

The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.

Urea compound for antagonizing LPA1 receptor

The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect:A-Y&#x2003;&#x2003;[1]wherein  

Phenyl tetrahydroisoquinoline compound substituted with heteroaryl

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof. 

Hydroxamic acid derivative

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof: 

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.

Isoquinoline derivative

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Tokyo, Japan

Fumito Uneuchi