Ss Pharmaceutical Co., Ltd.

Toshin Chemical Co., Ltd.

Life Science Laboratories Co., Ltd.

Fumitake Shimada

Tetsuro Ikekawa

Kazuo Uebaba

Susumu Ishiguro

Kenichi Ishibashi

Akiko Ikekawa

Toshio Itoh

Jong-Chol Cyong

EEM-S obtained by extracting with hot water or a lower alcohol at least one mushroom selected from among ver. , blanc du pays, and , treating the obtained extract by the molecular sieve method and thus eliminating low-molecular-weight and high-molecular-weight fractions: and preparations thereof. This EEM-S exerts physiological effects such as anticancer, immunopotentiating, antioxidative, hypotensive and hypoglycemic effects.

Physiologically active substance EEM-S originating in mushrooms, process for producing the same and drugs

A 13-propylberberine salt, which is represented by the following general formula (I): ##STR1## wherein X.sup.- means HSO.sub.4 or H.sub.2 PO.sub.4, has strong inhibitory effect against secretion, good stability and high water solubility. Its effects are shown promptly after its oral administration.

13-propylberberine salts

A novel and efficient method is proposed for the preparation of isosorbide-5-nitrate which is a promising medicinal compound for several diseases due to disorder in heart. The method comprises direct nitration of isosorbide with a concentrated nitric acid in a specific reaction medium containing an aromatic hydrocarbon solvent, e.g. benzene, in addition to conventional acetic acid and acetic anhydride. After neutralization of the reaction mixture and removal of the dinitrate as a byproduct therefrom, the reaction mixture is admixed with an aqueous solution of sodium hydroxide so that a sodium salt of isosorbide-5-nitrate is precipitated in the form of a hydrate, which is a novel compound not known in the prior art. This hydrate sodium salt is then decomposed with an acid to give the desired isosorbide-5-nitrate in a high yield.

Method for the preparation of isosorbide-5-nitrate and sodium

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Kasukabe, Japan

Fumitake Shimada