Mandom Corporation

Osaka University

Takasago International Corporation

National Institutes of Biomedical Innovation, Health and Nutrition

Fumitaka Fujita

Kiyotoshi Sekiguchi

Fumihiro Okada

Ryuichiro Kurata

Kenya Ishida

Kenji Maruyama

Ken Ishii

Hironori Shimizu

Ichiro Katayama

Atsushi Tanemura

Kie Nakashima

Hiroyuki Murota

Masayuki Takaishi

Shu Sakuyama

Tomohisa Hayakawa

Manami Toriyama

Shimizu Hironori

Ishida Kenya

Sakuyama Shu

Takaishi Masayuki

Maruyama Kenji

Provided is a method whereby an objective indicator of an immune-related disease can be rapidly and easily detected, the method comprising detecting, as an indicator of an immune-related disease, a difference in the result of observing a primary cilium of an immune-related cell between a subject specimen and a normal specimen.

Method for detecting indicator of immune-related disease

This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R, R, Rand Reach independently represent a hydrogen atom or a methyl group, and R, R, Rand Reach independently represent a hydrogen atom, a methyl group or &#x2014;O&#x2014;R&#x2014;OH (in the formula, Rrepresents an alkylene group optionally having a substituent group), provided that at least one group of R, R, Rand Ris &#x2014;O&#x2014;R&#x2014;OH. 

TRPA1 activity inhibitor

A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.

Method for observing dynamics of sweat glands

An immortalized sweat gland myoepithelial cell which expresses &#x3b1;-SMA and pan-cytokeratin and has a sphere forming ability after subculture at least 5 times. A method for producing immortalized sweat gland myoepithelial said method comprising: while culturing a cell structure, wherein sweat gland myoepithelial cells are exposed on a surface, in a state of being suspended in a medium, transferring an immortalizing gene into the cells; and then culturing the transgenic structure thus obtained in a state of being suspended in the medium to thereby obtain immortalized sweat gland myoepithelial cells.

Immortalized sweat gland myoepithelial cell

Growing community of inventors

Osaka, Japan

Fumitaka Fujita