Kureha Kagaku Kogyo Kabushiki Kaisha

Kureha Chemical Industry Company, Limited

Fumio Tamura

Kiro Asano

Tsuyoshi Saito

Satoshi Mitsuhashi

Tadahiro Matsudaira

Atsushi Tomonaga

Yoshio Kawai

Kiyoshi Yamaki

A biochemical information processing apparatus includes a storage means storing biochemical information, input means for accepting input of data, reaction scheme detection means for detecting a chemical reaction scheme involving a compound, based on the data, and display means for displaying a reaction scheme diagram of the chemical reaction scheme. The storage means includes a compound information file, an enzyme information file, and a relation information file. The relation information file stores a list showing the relation among compound numbers of compounds, enzyme numbers of enzymes with either pertinent compound being a substrate, and enzyme numbers of enzymes with either pertinent compound being a product. The reaction scheme detection means includes a first process portion for preparing canonical data of the compound from the data and searching the compound information file based thereon to read out a compound number. It also includes a second process portion for reading an enzyme number of an enzyme with the compound being a substrate or a product, a third process portion for reading a compound number of another compound constituting a reaction system with the enzyme and additional information of the enzyme, and a fourth process portion for indicating a reaction scheme diagram of the compound on the display means.

Biochemical information processing apparatus, biochemical information processing method, and biochemical information recording medium

Displaying method of reaction path diagram of compound

The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different.

Method for suppressing an immunoresponse with an estradiol

An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.

Estradiol derivative-chlorambucil conjugate, process for preparing the

Estradiol derivative-chlorambucil conjugate process for preparing the

A process for manufacturing homogeneous and low porosity carbon articles of great mechanical strength from a composition including a sinterable mother material and an additive selected from the group consisting of hydrocarbons, fatty acids, esters and salts of fatty acids, organic compounds having OH functional groups and mixtures thereof, wherein the mother material has an H/C atomic ratio of 0.3 to 0.75, a fixed carbon value of 55 to 96% and does not flow out of a 1 mm diameter nozzle at a temperature of 300.degree. C. under a load of 10 kg/cm.sup.2 ; and the additive has a fixed carbon value of 20% at most, a boiling or decomposition point of at least 150.degree. C. and becomes fluid at a temperature of at least 100.degree. C.

Raw composition for carbon articles

Growing community of inventors

Ibaraki, Japan

Fumio Tamura