Otsuka Pharmaceutical Company, Limited

Otsuka Pharmaceutical Factory, Inc.

Japanese Foundation for Cancer Research

Fumio Shimizu

Kenichi Imagawa

Haruo Sugano

Masatoshi Inai

Mitsuru Hirohashi

Yoshihito Yamamoto

Mitsuaki Yoshida

Setsuro Fujii

Takashi Sakamoto

Kazuhiko Tsutsumi

Tetsuhiko Shirasaka

Shizuo Nakamura

Nobuhiro Ikei

Yasukazu Ohmoto

Setsuro Fujii, Deceased

Tetsuya Tachikawa

Naosumi Kinoshita

By Kaoruko Takada, Successor

Etsuro Hashimura

Atunari Noda

Kenji Shima

Shin Sadahito

Yoshito Nakajima

Makiko Matsuura

Yasuo Ohe

By Shinichiro Fujii, Successor

By Keiko Fujii, Successor

Novel polypeptide derivatives, acid-addition salts thereof and complexes thereof, having the activities for inhibiting bone calcium absorption, for lowering the blood level of calcium, as analgesics, for inhibiting secretion of the gastric juice. Pharmaceutical composition can be prepared by formulating, at least one of the novel polypeptide derivatives, acid-addition salts thereof and complexes thereof, together with a proteolytic enzyme inhibitors and/or pharmaceutically acceptable acids. The pharmaceutical composition are quite effective as agents for curing hypercalcemia, for curing Peget's disease, for curing osteoporosis, analgetic agent, anti-ulcerative agent and the like.

Polypeptide derivatives and calcium metabolism improving agent

Novel synthetic polypeptide derivatives, i.e., novel calcitonin derivatives, having improved basic physiological activities of the corresponding natural calcitonins, i.e., the activity for lowering the blood level of calcium, the activity as an analgesic, as well as the activity for inhibiting the secretion of the gastric juice. Thus these synthetic calcitonins are effective as agents for curing hypercalcemia, analgetic agents, anti-ulcerative agents and the like.

Polypeptide derivatives

For the diagnosis of diabetes, a glucosylated protein in a sample is measured by subjecting the sample to a reducing treatment and then detecting a compound, which contains one or more reduced glucosylated lysine residual groups, in accordance with an immunoassay technique in which the reduced glucosylated lysine residual groups are used as an epitope.

Monoclonal antibody, measuring method of glucosylated protein by

An antibody of a human leukemia virus-related peptide obtained by collecting an antibody produced in a mammal body by administering to the mammal an antigen prepared by reacting a human leukemia virus-related peptide selected from the group consisting of:

Antibodies to human leukemia virus-related peptides and a process for

An antibody of a human leukemia virus-related peptide obtained by collecting an antibody produced in a mammal body by administering to the mammal an antigen prepared by reacting a human leukemia virus-related peptide represented by formula (1):

Human leukemia virus-related peptides, a process for production thereof,

Human leukemia virus-related peptides, antibodies of the peptides and a

Human interferons related peptides and derivatives thereof, antigens, antibodies prepared therefrom, immobilized antibodies to be used for affinity chromatography, and novel method for assaying human interferons by using said affinity chromatography.

Human interferon-related peptides, antigens, antibodies and process for

Growing community of inventors

Tokushima, Japan

Fumio Shimizu