Hitachi, Ltd.

Hitachi Medical Corporation

Other

Gunma University

Eizo Nanao Corporation

Tokai University

Fumio Kawaguchi

Atsushi Maki

Yoshitoshi Ito

Yuichi Yamashita

Hideaki Koizumi

Noriyoshi Ichikawa

Minoru Yoshida

Shingo Kawasaki

Michiyuki Fujiwara

Tsuyoshi Yamamoto

Hiroshi Takeuchi

Hideo Kawaguchi

Mikihiro Kaga

Naoki Tanaka

Yasuhiro Mitsui

Keiichi Nagai

Ken Ueda

Yukiko Hirabayashi

Katsumi Takami

Teruichi Tomura

Masato Fukuda

Hideji Fujii

Manabu Nakagawa

Kenji Ishimatsu

Munetaka Haida

Masahiko Mikuni

Tetsuhiko Takahashi

Hiromichi Yamada

Hiroki Sato

Kazuo Takeda

Masashi Kiguchi

Kensuke Sekihara

Keiji Umetani

Tsuneaki Kawaguchi

Hiroyuki Kohida

Atsushi Suzuki

Takayuki Hayakawa

Yukari Yamamoto

Kouichi Koike

Mitsuo Ohashi

Takushige Katsura

Takeshi Tajima

Katsue Ueda

Motohiro Kurisu

Yukito Shinohara

Adi Bonen

There is provided a system for supporting the assessment as to which disease group the subject to be examined falls in or what position in the whole disease group the subject is in. This support system comprises the data storage part which stores feature values of optical bio-measurement data of many subjects including patients in multiple disease groups, the analysis part which extracts plural kinds of feature values from the optical bio-measurement data and the display part which displays the results of analysis in the analysis part associated with the dictionary data, wherein the display part produces a scatter diagram on which features values of the dictionary data are plotted, with one of the two feature values being plotted along the axis of abscissa and the other along the axis of ordinate, and displays the positions of the subject to be assessed on the scatter diagram superimposed on the scatter diagram. With this scatter diagram, the relationship between the features of the subject and the feature of the disease group can be known in one glance.

Disease diagnosis support system

In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

Optical system for measuring metabolism in a body and imaging method

A living body information signal processing system () combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus () in which inspection light of from visible to near infrared is irradiated on a head portion of a subject () and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus () which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device () used for both apparatus; and a living body information signal processing and displaying device () which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.

Living body information signal processing system combining living body optical measurement apparatus and brain wave measurement apparatus and probe device used for the same

A biological optical measurement instrument including: a measurement probe positionable to a surface of a subject, which irradiates light beams having a plurality of wavelengths from a light beam source through optical fibers onto the subject, and collects the light beams passed inside the subject from a plurality of positions to facilitate production of diagnostics from collected light beams of the subject, wherein the measurement probe is provided with probe casings which hold the optical fibers, fixing members where each respective fixing member is mateable with a respective probe casing to position the probe casings in a predetermined interval, and a support member which supports the fixing members, and wherein at least one of the respective probe casing or the respective fixing member is provided with a stopper claw to permit fixed engagement of the respective probe casing with the respective fixing member upon mating thereof.

Biological optical measurement instrument

An apparatus which can objectively assess and display to what extent and to which disease the subject belongs based on the signals of changes in hemoglobin amount measured by the optical measurement apparatus is provided. The disease assessment apparatus comprises the feature extraction unitfor extracting features of the hemoglobin waveform, the feature analysis unitand the storage unitfor storing features by each disease as database. The disease is assessed by extracting various kinds of feature amounts from the hemoglobin signals of the subject measured by the optical measurement apparatus in the feature extraction unitand by applying multivariate analysis of similarities between feature amounts extracted and feature amounts stored by disease in the storage unitResults of assessment are shown as scores expressing similarity with each disease group in a bar graph.

Optical measurement apparatus for living body

A biological light measuring instrument for illuminating a subject with a plurality of beams of light from a plurality of illuminating positions, measuring the light beams transmitted through the subject, and creating a topographic image showing ecological information about the inside of the subject, comprising unit for creating three-dimensional coordinate data representing the relationship among the illuminating positions and a reference point on the subject and the relationship between the light measuring position and the reference point, unit for setting the illuminating positions and light measuring position on a three-dimensional shape image of the subject according to the three-dimensional coordinate data, and unit for creating a three-dimensional topographic image according to the three-dimensional coordinate data, and unit for superposing the three-dimensional topographic image on the shape image while maintaining the relationships of the illuminating positions and the light measuring position.

Biological light measuring instrument

The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.

Biological photometric device

A biological optical measuring instrument comprising a measuring probe () for collecting light from a plurality of portions of a subject () transmitted through the subject () by means of an optical fiber () by guiding light emitted from a light source () by an optical fiber (), and irradiating the light to the subject () so as to create a living body transmitted light intensity image of the subject () from the transmitted and collected light. The measuring probe () further comprises optical fiber fixing members () for fixing the optical fibers () at a predetermined interval and support members () for rockably supporting the optical fiber fixing members. Thus, it is possible to provide a technique of performing living body optical measurement while the living body lies in lateral decubitus.

Biological optical measuring instrument

A two-dimensional monochrome bit face display has a luminance resolution that is equal to or higher than that of a CRT monitor. In one implementation, a two-dimensional monochrome bit face display has a bit face in which each pixel is constituted by m sub-pixels and neutral density filters mounted on the m sub-pixels of a respective pixel have light transmittances proportional to values &#xbd;where n is an integer. In another implementation, mask filters are mounted on the m sub-pixels and have windows with light transmittances that are proportional to values &#xbd;. Alternatively, areas of the m sub-pixels are set in the same proportion. The luminance of each sub-pixel is electronically controlled to improve the luminance resolution of the bit face display.

Two-dimensional monochrome bit face display

A highly reliable optical measuring instrument for multi-channel simultaneous measurement has an intensity of light emitted from a light source modulated at different frequencies and the light is applied to multiple positions of a test object. The light which is detected from the test object is converted into electric signals by a photodiode, and modulation signals are detected by a lock-in amplifier module. The signals are processed as information on the test object interior by a processing unit. Light is applied sequentially from a light source in a preparatory measurement step prior to final measuring, and the signal level of the detection light is measured for each light applied position. A control unit controls light intensity and detection signal level to ensure that the difference in detection light levels is kept within a specified range.

Optical measuring instrument

In a system for performing imaging measurement of a test object by mounting many optical fibers to the test object, incident positions of the test object on which to illuminate light, detection positions of the test object from which to detect light and measurement positions which are determined from a positional relationship between the incident positions and the detection positions are displayed as graphic elements on a display unit. A state of detection signal level or a change in the state is displayed as a change in color or in pattern of the graphic element. Further, incident optical fibers for illuminating light to the test object and detection optical fibers for detecting light from the test object are mounted to the test object, and light emitting elements are mounted to probes to be mounted to the test object and interlocked with the change of the graphic elements.

Optical measurement equipment and recording medium and optical measurement method

Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in. hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by the two light detectors disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.

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Tokyo, Japan

Fumio Kawaguchi