Cosmed Pharmaceutical Co., Ltd.

Sekisui Kagaku Kogyo Kabushiki Kaisha

Strakan Limited

Nipro Patch Co., Ltd.

Kabushiki Kaisha Sakamura Kikai Seisakusho

Osaka University

Kobe University

Public University Corporation Nara Medical University

Fumio Kamiyama

Ying-shu Quan

Ying-Shu Quan

Naoko Kondou

Ying-Zhe Li

Hiroshi Tanaka

Kiyotsune Higuchi

Minoru Kohara

Akira Yamamoto

Tomoya Yamada

Mio Saito

Shouta Kitaoka

Takao Taki

Kazutoshi Yamazaki

Shinsaku Nakagawa

Mituo Nagata

Naohisa Kawamura

Kazuhide Ohta

Hidenori Sawada

Yasuhiko Araki

Kazuyoshi Kawai

Yoshikazu Sakamura

Takuya Hamabuchi

Hirofumi Yamashita

Hidemasa Katsumi

Tomoya Kitagawa

Yoshikazu Tobinaga

Kunio Yoneto

Ying Shu Quan

Junya Hasegawa

Tadayoshi Takemoto

Kentaro Ohshima

Sachiko Hirobe

Naoki Okada

Hideo Asada

Rongrong Jiang

Tooru Ooya

Takashi Amakawa

Ying Quan

Adhesive patch

The present invention provides a drug-holding microneedle array in which a drug is applied and held only on a tip portion of microneedles for quantitatively holding the drug and for preventing the drug from falling away during insertion of the microneedles. The drug-holding microneedle array comprises: a microneedle array having a microneedle substrateand microneedles, the microneedles being positioned in plural on the microneedle substrateand a tip portionof the microneedles projecting via steps; and a drug held on the tip portion of the microneedles and the steps

Drug-holding microneedle array and manufacturing method thereof

Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum.

Protective release sheet for microneedle patch

To develop a novel administration method of a fucoidan-containing hair-growing agent and to provide a means for exerting excellent effects of a fucoidan. A hair-growing agent of the present invention is characterized in that it is composed of a combination of a fucoidan-containing microneedle and a fucoidan-containing liniment. A base of the fucoidan-containing microneedle is preferably a biosoluble polymer. A hair-growing method of the present invention is characterized in that the fucoidan-containing microneedle and the fucoidan-containing liniment are concomitantly used.

Fucoidan hair growth agent

A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided. The cosmetic gel sheet of the present invention contains carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential constituent components. Carboxy group-containing polysaccharide can be suitably used as the carboxy group-containing water-soluble polymer. Water content in the gel sheet is 30% by weight, but it is more preferable if the water content is 10% by weight or less. In the cosmetic gel sheet of the present invention, the gel sheet can be manufactured by drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol, and acid as essential components. Wherein, it is desirable that content of the acid in the aqueous solution is adjusted to a value appropriate for setting pH of the aqueous solution to 2.0-4.0.

Cosmetic gel sheet and manufacturing method thereof

A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation, which is composed of a liquid container and the nozzle.

Applicator for water-soluble sheet-shaped preparation

To provide a means which makes it possible to hold a microneedle array without an adhesive sheet and protect tips of microneedles. A foam support sheet for a microneedle array, which has an open cell surface on at least one side, the open cell surface being an arrangement portion for the microneedle array holding the microneedle array with a microneedle side of the microneedle array facing downward; as well as a microneedle array sheet consisting of a microneedle array and a foam support sheet, the foam support sheet having an open cell surface on at least one side, and the microneedle array being arranged on the open cell surface with a microneedle side of the microneedle array facing downward.

Foam support sheet for microneedle array

Providing a patch case that is easily attached to a microneedle applicator, easily separable from the microneedle patch upon insertion and disposable for use. The main feature of the patch case according to the present invention is characterized in that it is made of a thermoplastic polymer and is capable of holding a microneedle patch comprising a support film which can be heat-sealed with the thermoplastic polymer. Preferably, the thermoplastic polymer of the body and the fusible material of the support film are both polyolefins or both are the same thermoplastic polymer. In addition, if the patch case is attached to the front of the applicator, sanitary situation can be maintained even with continuous use of the applicator, since the applicator does not contact the skin of the recipient.

Microneedle patch case

A nozzle having at least one hole on an end portion having a plane with a size capable of holding a sheet-like water-soluble preparation. The nozzle also has concave-convex portions on a portion of the plane excluding the hole. An applicator for a sheet-like water-soluble preparation which is composed of a liquid container and the nozzle.

A cosmetic gel sheet suitable for a cosmetic field or a medical field is provided. The cosmetic alcogel sheet of the present invention comprises: a water-soluble nonwoven fabric or a water-soluble film; and an alcogel which is laminated on it and contains carboxy group-containing water-soluble polymer, polyalcohol and acid as essential components, and the sheet is characterized in that the water content of the gel is 30% by mass or less. It is more preferred that the carboxy group-containing water-soluble polymer is carboxy group-containing polysaccharides, and the polyalcohol is glycerin. The cosmetic alcogel sheet of the present invention can be manufactured by: drying an aqueous solution containing carboxy group-containing water-soluble polymer, polyalcohol and acid as essential components on a releasable sheet to manufacture gel, and then laminating the gel on a water-soluble nonwoven fabric or a water-soluble film.

Alcogel sheet for cosmetic use, and method for producing same

To provide a composition of a coating liquid for microneedle which is optimal for coating a microneedle with a medicinal ingredient. The coating liquid for microneedle of the present invention is an aqueous solution containing, as essential components of a base, a water-soluble polysaccharide, a monosaccharide and/or a disaccharide and a surfactant, characterized in that a ratio of the water-soluble polysaccharide to the base is 2 to 60 mass %, and the hardness after being dried is 10 N or more. The coating liquid for microneedle may further contain a water-soluble polyalcohol, and preferably a monosaccharide and/or a disaccharide is 30 to 95 mass %, a surfactant is 0.05 to 5 mass %, and a water-soluble polyalcohol is 10 mass % or less in the base. As the water-soluble polysaccharide, hydroxypropyl cellulose, hyaluronic acid, or carboxymethyl cellulose is preferable.

Coating liquid for microneedles, microneedle-coating substance, and microneedle array

The present invention provides a drug-holding microneedle array in which a drug is applied and held only on a tip portion of microneedles for quantitatively holding the drug and for preventing the drug from falling away during insertion of the microneedles. The drug-holding microneedle array comprises: a microneedle array having a microneedle substrateand microneedles, the microneedles being positioned in plural on the microneedle substrateand a tip portionof the microneedles projecting via stepsand a drug held on the tip portion of the microneedles and the steps

To suppress the work cost for the washing of the microneedle and the application of the medicament. A microneedle patch storage tool according to one aspect of the present invention is a microneedle patch storage tool for storing a microneedle patch and comprises a plurality of pallets stacked in a vertical direction, and the two pallets adjacent in the vertical direction constitute one or a plurality of patch holding parts for holding the microneedle patch, and the patch holding part comprises a plurality of lower protrusions arranged in circumferentially divided manner so as to sandwich a peripheral edge part of the microneedle patch in the vertical direction and supporting the peripheral edge part of the microneedle patch from a lower side and a plurality of upper protrusions arranged in circumferentially divided manner and pressing the peripheral edge part of the microneedle patch from an upper side and is opened to at least one of upper and lower directions.

Microneedle patch storage tool, lower pallet and upper pallet

Growing community of inventors

Kyoto, Japan

Fumio Kamiyama