Kyoto Pharmaceutical Industries, Ltd.

Fumio Fukata

Hiroaki Shirahase

Akihisa Yoshimi

Hiroshi Matsui

Shohei Nakamura

Kazuhiko Kitao

Nobuharu Kakeya

Hideki Okunishi

Takayoshi Mori

Mamoru Kanda

Yuta Kobayashi

The cromoglycic acid compound of the formula (I)

Medicinal use of cromoglycic acid compounds

Antirheumatic agent

1,4-Dihydropyridine derivatives of the general formula: ##STR1## wherein X.sup.1 and X.sup.2 independently represent hydrogen, fluoromethyl, fluoromethoxy, halogen, cyano, or nitro; R.sup.1 represents a lower alkyl; R.sup.2 represents acyl, alkoxycarbonyl, acylalkyl, an N-alkyl-substituted carbamoylalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyloxyalkyl, nitratoalkyl, cyanoalkyl, heterocycle-alkyl, haloalkyl, alkenyl, or alkynyl; A represents an alkylene comprising a carbon atom to which 2 alkyls are bonded and having in total at least 5 carbon atoms; m represents the integer 1, 2 or 3; acid addition salts thereof; a method of production thereof; and pharmaceutical compositions containing such compound(s). Such compounds have pharmacological activities, in particular potent and long lasting hypotensive activity, coronary vasodilatation, cerebral vasodilatation, peripheral vasodilatation, renal vasodilatation and platelet aggregation inhibitory activity.

1,4-dihydropyridine derivatives and pharmaceutical composition thereof

Growing community of inventors

Osaka, Japan

Fumio Fukata