Ishihara Sangyo Kaisha, Ltd.

Fuminori Kato

Kazuhiro Yamamoto

Hirohiko Kimura

Takashi Okada

Keizo Miyata

Hiroyuki Ikegami

Hiromi Takeo

Shuichi Yotsuya

Kenji Kon

Mitsuo Sano

Masato Omatsu

Sadanori Mizukoshi

Toshihiko Ueki

Shunji Yuki

Kiyoshi Tamai

Yoshitaka Kondo

Kumiko Azuma

Shinya Mori

Ryuji Miyamoto

Masamitsu Tsukamoto

This invention discloses a preserving agent for organs or tissue comprising (A) quercetin, and (B) at least one sugar selected from the group consisting of fructose and sucrose; a preserving solution for organs or tissue comprising the preserving agent; and a preservation method for organs or tissue comprising the step of immersing an organ or tissue in a liquid mixture comprising (A) quercetin, and (B) at least one sugar selected from the group consisting of fructose and sucrose.

Preserving agent for organs or tissue and preservation method for organs or tissue

This invention relates to a monoclonal antibody against a human HIG-1 polypeptide, the antibody binding to at least one epitope included in the amino acid sequence at positions 1-19 of a human HIG-1 polypeptide; an antibody fragment derived from the antibody; a DNA comprising a base sequence encoding a variable region of the antibody; an expression vector comprising the DNA; a cell line producing the antibody; a reagent for detecting a human HIG-1 polypeptide comprising the antibody or the antibody fragment, and a method for detecting a human HIG-1 polypeptide using the antibody or the antibody fragment.

Monoclonal antibody against human HIG-1 polypeptide

To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C&#x2014;NOor C&#x2014;CN; Hal is a halogen; Mis alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO; Mis amino, O, S or a single bond; Ris a halogen, alkyl or the like; each of R, R, Rand Ris independently H, alkyl or the like; Ris a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.

Thioamides and salts thereof and cytokine production inhibitors containing both

The present invention provides a cytokine production inhibitor containing as an active ingredient an aniline derivative of the formula (I) or a salt thereof: [wherein A is CO or SO; Cy is an aryl group or a heterocyclic group; each of Rand Rwhich are independent of each other, is a halogen atom, a cyano group, a nitro group, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, a cycloalkenyl group which may be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an amino group which may be substituted or a &#x2014;B-Q group; Ris a -M-M-Rgroup; Ris a hydrogen atom or an alkyl group which may be substituted; x is an integer of from 0 to 5; y is an integer of from 0 to 4; and z is an integer of from 0 to 1].

Aniline derivatives or salts thereof and cytokine production inhibitors containing the same

The present invention provides a preventive or therapeutic medicine for diabetes containing as an active ingredient a fused-heterocyclic compound of the formula (I') or its salt: [wherein G is CN, NO, COR, CHO, SONRRor CONRR; Ris a halogen atom, a &#x2014;O&#x2014;Rgroup or a &#x2014;S&#x2014;Rgroup; Ris a halogen atom, a &#x2014;O&#x2014;Rgroup (wherein Ris as defined above) or an amino group which may be substituted; and each of Rand Rwhich are independent of each other, is a hydrogen atom, a halogen atom or an alkyl group].

Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts

Medical composition containing nitroetheneamine Derivative or salt there of as active constituent

Medical composition containing nitroetheneamine derivative or salt thereof as active constituent

An immuno-suppressive agent containing, as an effective component, an, enopyranose derivative of the following formula (I) or its salt: ##STR1## wherein R.sup.1 is a hydrogen atom, alkyl which may be substituted, alkenyl, alkynyl, --OSO.sub.2 R.sup.7, a halogen atom, --OCOR.sup.7, --NHCOR.sup.8, alkoxy, phenyl which may be substituted or a saccharose residue, R.sup.2 is a hydrogen atom or alkyl, R.sup.3 is a hydrogen atom or a halogen atom, R.sup.4 is a hydrogen atom, --COR.sup.9, silyl which may be substituted or alkyl which may be substituted, one of R.sup.5 and R.sup.6 is hydroxyl, alkoxy which may be substituted, a saccharose residue, cycloalkyloxy which may be substituted or --OCOR.sup.10 and the other is a hydrogen atom or alkyl which may be substituted, or R.sup.4 and R.sup.5 together form a single bond, while R.sup.6 is a hydrogen atom or alkyl which may be substituted, each of R.sup.7, R.sup.9 and R.sup.10 is alkyl or phenyl which may be substituted, R.sup.8 is alkyl, phenyl which may be substituted or benzyloxy, X is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted, pyridyl which may be substituted, furanyl which may be substituted, thienyl which may be substituted, formyl, --COR.sup.11, --C(W.sup.1)W.sup.2 R.sup.11 or --SO.sub.2 R.sup.11, R.sup.11 is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted, or a polycyclic heterocycle group which may be substituted, W.sup.1 is an oxygen atom or a sulfur atom, W.sup.2 is an oxygen atom, a sulfur atom or --NH--, Y is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted or alkynyl which may be substituted.

Immuno-suppressive agent

Growing community of inventors

Shiga, Japan

Fuminori Kato