Daiichi Sankyo Company, Limited

Fuminao Doi

Takeshi Masuda

Kensuke Nakamura

Hiroaki Uchida

Takashi Nakada

Yusuke Ota

Shinji Ashida

Mitsuhiro Iwamoto

Narihiro Toda

Ichiro Hayakawa

Daisuke Okajima

Hirofumi Hamada

Tomoko Terauchi

Masaki Meguro

Naoya Harada

Shoko Yoshida

Hidenori Namiki

Tsuyoshi Soneda

Shigeo Yamanoi

Yuichi Ochiai

Madoka Hoshino

Katsuji Kagechika

The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

Methods of treating a tumor by administering a claudin-6 (CLDN6) or CLDN9 antibody-pyrrolobenzodiazepine derivative conjugate

Provided are novel antibody-pyrrolodiazepine derivative and novel antibody-pyrrolodiazepine derivative conjugates, as well as methods of using the same, and a novel CLDN6 and/or CLDN9 antibody. The disclosed compounds are of the class of alkyl benzene sulfonyl ureas, useful as oral anti-diabetics, and include substituted benzo[e]pyrrolo[1,2-α][1,4]diazepine.

Antibody-drug conjugates comprising substituted benzo[e]pyrrolo[1,2-a][1,4]diazepines

A novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, comprising substituted benzo[e]pyrrolo[1,2-a][1,4]diazepines represented by the [Formula 24], [Formula 25], [Formula 26], and/or [Formula 27].

Antibody-drug conjugates comprising substituted benzo[e]pyrrolo[1,2-&#x3b1;][1,4]diazepines

Antibody-pyrrolobenzodiazepine derivative conjugate and method of use thereof for treating a tumor

The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent glucose lowering effect. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: wherein Rrepresents a C1-C3 alkyl group, each substituent Rmay be the same or different and may each represent a C1-C3 alkyl group, Rrepresents an optionally substituted pyridyl group or the like, Rand R, which are the same or different, each represent a C1-C3 alkyl group, Rand R, which are the same or different, each represent a C1-C3 alkyl group, and n represents 0 to 3.

Phenylxanthene derivatives

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Tokyo, Japan

Fuminao Doi