Canon Kabushiki Kaisha

Fumiko Tomatsu

Tatsuki Fukui

Atsushi Takahashi

Daisuke Sasaguri

Masato Minami

Kengo Kanazaki

Kouichi Kato

Tetsuya Yano

Yoshinori Tomida

Satoshi Yuasa

Keigo Mizusawa

Sachiko Inoue

Mayuko Kishi

Shinzaburo Ito

Hiroyuki Aoki

The present invention provides contrast agents for photoacoustic imaging which exhibit high degrees of accumulation in tumor and low degrees of retention in the blood and can be administered into the blood. The contrast agents for photoacoustic imaging include a conjugate of a dye and a polyethyleneglycol represented by Formula (1), (5), (6), or (7) and an additive represented by Formula (301). 

Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same

A method for producing a contrast agent includes the reaction step of allowing a cyanine dye containing a naphthyl group and a carboxyl or carboxylate group to react with a polyethylene glycol containing an amino group in an organic solvent to form a conjugate, and the purification step of purifying the conjugate using an organic solvent.

Method for producing contrast agent

Provided is a particle which can stably hold a dye in itself even in an aqueous solution such as serum, in order to solve such a problem of a particle containing ICG, which has been conventionally used in a contrast agent or the like, that the ICG is a dye having a hydrophilic functional group and hence the ICG leaks out of the particle in an aqueous solution such as serum. More specifically, provided is a particle including a hydrophobic dye having a cyanine structure, in which the hydrophobic dye is represented by the following chemical formula (1). 

Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle

A particle includes a copolymer of lactic acid and glycolic acid, and at least one compound selected from silicon naphthalocyanine and derivatives of silicon naphthalocyanine, in which the particle has a particle size of 10 nm or more and less than 1000 nm.

Particles and contrast agent including the same for optical imaging

A compound represented by Formula (1) below, where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; Rto Reach independently represent a hydrogen atom or a sulfonate that is any one of sodium sulfonate, potassium sulfonate, ammonium sulfonate, triethylammonium sulfonate, pyridinium sulfonate, lysine sulfonate, and arginine sulfonate; and Rto Reach independently represent a substituted or unsubstituted C1-C3 alkyl group.

Compound, probe containing the novel compound, and fluorescence-imaging contrast agent containing the novel compound or the probe

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Yokohama, Japan

Fumiko Tomatsu