Fuso Pharmaceutical Industries, Ltd.

Kinki University

The University of Toyama

Fumiko Sekiguchi

Atsufumi Kawabata

Hiroyuki Nishikawa

Hideaki Matsuda

Kazuya Murata

Naoki Toyooka

Maho Tsubota

A new analgesic has been developed for T-type calcium channels as therapeutic targets. The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1):  The present invention also provides this T-type calcium channel inhibitor, a medicament containing the T-type calcium channel inhibitor, and a therapeutic or prophylactic agent for a disease having an effective T-type calcium channel inhibitory action.

T-type calcium channel inhibitor

The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action. (In formula (1), each of Rand Rindependently represents H, &#x2014;OH or &#x2014;ORwherein Rrepresents a Calkyl group; each of Rand Rindependently represents H, &#x2014;OH or &#x2014;OR, wherein Rrepresents a Calkyl group; and each of Rand Rindependently represents H, a halogen atom, a Calkyl group, a Calkenyl group, a Calkynyl group, a phenyl group (which may be substituted by a Calkoxy group or a halogen atom), a &#x2014;Calkyl-phenyl group (which may be substituted by a Calkyloxy group or a halogen atom) or a Cprenyl group.) 

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Higashiosaka, Japan

Fumiko Sekiguchi