Msd K.k.

Banyu Pharmaceutical Co. Ltd

Fumiko Sakai

Teruyuki Nishimura

Jun-ichi Eiki

Yasuhiro Sasaki

Morihiro Mitsuya

Makoto Bamba

Hitomi Watanabe

Yoshio Ogino

Makoto Ishikawa

Keiji Takahashi

Katsumasa Nonoshita

Daisuke Tsukahara

Keisuke Arakawa

Noriaki Hashimoto

Yoshikazu Nagae

Hiroshi Nakashima

Chisato Nakama

Jun-Ichi Eiki

The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein Xrepresents a nitrogen atom, sulfur atom, oxygen atom or the like; Rrepresents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; Rand Rare the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

2-pyridinecarboxamide derivatives

A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided. The invention relates to a compound of a formula (I): [wherein Rand Rrepresent a hydrogen, etc.; Rrepresents a hydrogen atom, a halogen atom, etc.; Reach independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); Rand Reach represent a hydrogen atom, a lower alkyl group, etc.; X, X, Xand Xeach independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group &#x3b2;; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of Xto Xare carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.

Aryloxy-substituted benzimidazole derivatives

A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided. A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; (in the formula, X represents a carbon atom or a nitrogen atom); Rrepresents an aryl, etc.; Rrepresents a hydroxy, etc.; Rrepresents a &#x2014;Calkyl, etc.; Rrepresents a &#x2014;Calkyl, etc.; Xrepresents &#x2014;O&#x2014;, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].

2-heteroaryl-substituted benzimidazole derivative

2-pyridine carboxamide derivatives

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Hokkaido, Japan

Fumiko Sakai