Burnham Institute for Medical Research

Sanford-burnham Medical Research Institute

Fumiko Axelrod

Jeffrey W Smith

Steven J Kridel

Daniel Romo

Vikram C Purohit

Gil Ma

Sanjeev Satyal

Timothy Hoey

Austin Gurney

The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

Method for the asymmetric synthesis of beta-lactone compounds

The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis.

Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation

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La Jolla, CA, United States of America

Fumiko Axelrod