Otsuka Pharmaceutical Company, Limited

Fumiki Harano

Shigeo Shinohara

Kosaburo Wakamatsu

Masahiko Tanaka

Mitsuaki Kawamura

Akihiro Aoki

Hideo Tanaka

Shinji Tsujimoto

Hiromichi Okuda

Kazuhiro Yagyu

Osamu Takasu

Misato Nakajo

Yoshiyuki Murata

Noboru Yoshino

Isamu Saeki

Kenji Kameda

Chie Morimoto

Shigekatsu Kawabata

Junko Kamimura

Yasuo Furuta

Takashige Koba

Eri Ueno

Shigekatsu 14-31 Nakanokoshi Kawabata

Noboru Igurukoto Nagitsuji 3-903 Yoshino

An object of the present invention is to provide a composition for external application that is applied to a part of the skin to more effectively elicit the useful effects of an adenine compound such as adenine, adenosine, and a phosphoric ester of adenosine, and that has long-lasting effects and enhanced skin-moisturizing effects. A gel composition for external application containing an adenine compound such as adenine, adenosine, and a phosphoric ester of adenosine is prepared by using agar as a gelling agent. The gel composition is further prepared in the form of a sheet-like adhesive patch. The gel composition in the form of a sheet-like adhesive patch is kept immersed in an aqueous solution containing the adenine compound.

Gel composition for external application containing an adenine compound

An object of the present invention is to provide an agent for suppressing the formation of skin cells induced by exposure to light such as ultraviolet light. The object is achieved by using a purine nucleic acid for suppressing the formation of abnormal skin cells caused by exposure to light.

Agent for suppressing the formation of abnormal skin cells caused by exposure to light

A composition for external use capable of more efficiently deriving the effect of purine substances (and/or salts thereof) including (A) sugar; and (B) at least one member selected from the group consisting of purine substances and salts thereof.

Composition for external application

The present invention provides an antiaging composition capable of efficiently retarding skin aging skin aging, particularly, alleviating skin pigmentation. The present invention also provides a method for potentiating the antiaging action of ascorbic acids. The invention provides an antiaging composition containing at least one member selected from the group consisting of ascorbic acid, a derivative of ascorbic acid, and a salt thereof (A), and a purine nucleic acid-related substance (B). The invention provides a method for potentiating the antiaging action of such component (A) by the combined use of at least one member selected from the group consisting of ascorbic acid, a derivative of ascorbic acid, and a salt thereof (A), with a purine nucleic acid-related substance (B).

Antiaging composition

The present invention aims to provide solid compositions comprising an oil-in-water emulsion that have sufficient hardness and good feel when used, and can sufficiently exhibit the physiological functions of an electrolyte. A solid composition is obtained by preparing an oil-in-water emulsion by combining a solid oil (A), a liquid oil (B), a surfactant (C), a polyhydric alcohol (D), an electrolyte (E), and water (F).

Solid oil-in-water emulsion

The present invention provides a composition that can effectively improve melasma and a composition that can effectively reduce skin dullness. The composition for improving melasma comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent melasma improving effect due to the action of the purine nucleic acid-related substance contained. The composition for reducing skin dullness comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent effect of reducing skin dullness due to the action of the purine nucleic acid-related substance contained.

Chloasma amelioration composition and dullness amelioration composition

An object of the invention is to provide a substance that activates saccharide uptake in epidermal cells and is thus expected to be effective in promoting skin cell neogenesis and metabolism. The invention provides a promoter for saccharide uptake in epidermal keratinocytes which comprises a purine base or a salt thereof as an active ingredient. The present invention further provides a method of promoting saccharide uptake in epidermal keratinocytes, comprising applying a purine base or a salt thereof to the skin.

Sugar intake promoters

Provided is a bar-like cosmetic delivering container which is internally sealed and suppresses the cosmetic from forming a play due to negative pressure and prevents the lipstick from contacting the inner surface of a lid sleeve body. The bar-like cosmetic delivering container adapted to project and retract the cosmetic by relative rotation between a receiving sleeve body and an outer sleeve body, wherein a lid sleeve body is provided with a sealing sleeve body adapted to fit on the outer sleeve body, thereby sealing the interior of the container. This ensures that even when the lid sleeve body is opened to release the sealing sleeve body, the receiving sleeve body alone is not internally subjected to negative pressure, preventing the lipstick from floating up or forming a play. Further, since the lid sleeve body and the outer sleeve body are fitted together by the sealing sleeve body, relative rotation between the lid sleeve body and the outer sleeve body does not deliver or screw out the lipstick in the container, never causing the lipstick to contact the top surface of the lid sleeve body.

Bar-like cosmetic delivering container

Growing community of inventors

Kyoto, Japan

Fumiki Harano