Taisho Pharmaceutical Co., Ltd.

Toyama Chemical Co., Ltd.

Fumihito Ushiyama

Taro Kiyoto

Hiroki Urabe

Toshiya Noguchi

Yasuhiro Tsutsui

Junichi Ando

Yasunobu Ushiki

Hiromasa Horikiri

Masato Takahashi

Tsuyoshi Shibata

Toru Yamaguchi

Tadashi Tanaka

Naoya Ono

Tetsuo Takayama

Yoshihisa Shirasaki

Yasuko Kawaguchi

Mai Motono

Mai Yokotani

Yoshinori Sekiguchi

Yuki Shimizu

Makoto Hamada

Takahiro Oi

Fumiyasu Shiozawa

Yusuke Oka

Tetsuya Tanikawa

Shoichi Kuroda

Yasutaka Baba

Daisuke Matsuda

Kenichi Kawabe

Akira Hiratate

Risa Tsuruta

Masahiro Takebayashi

Noritomo Fujino

Keiko Yamamoto

Ayumu Mori

Muneo Syoji

Sota Kato

Chie Koizumi

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I&#x2032;),W, Y, R, R, R, and Yare as described hereinabove), or pharmaceutically acceptable salts thereof.

Partially saturated nitrogen-containing heterocyclic compound

Provided are novel compounds that bind to FKBP12 or pharmaceutically acceptable salts thereof, as well as new therapeutics useful in the prevention or treatment of alopecia which comprise those compounds or pharmaceutically acceptable salts thereof. Specifically, compounds represented by formula (1) [where Rrepresents either the following formula (2) or (3)] or pharmaceutically acceptable salts thereof are provided.

Azole derivative

An amidine compound represented by formula (I) (wherein Arepresents a nitrogen atom or a group represented by formula CR; Aand Aare the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; Rrepresents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; Rand Rare the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a Calkyl group, a Chaloalkyl group or a Calkoxy group; and Rand Rare the same as or different from each other and independently represent a hydrogen atom, a Chaloalkyl group, a Calkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

Amidine compound or salt thereof

A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Quinolinones and quinoxalinones as antibacterial composition

Disclosed is a compound represented by the general formula: wherein Rrepresents an aryl or heterocyclic group which may be substituted or the like; Xrepresents a C-Calkylene group or the like; X, Xand Xindependently represent NH, a bond or the like; Xrepresents a lower alkylene group, a bond or the like; Yrepresents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z, Z, Z, Z, Zand Zindependently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z, Z, Zand Zrepresents a nitrogen atom, or a salt thereof, which is useful as an antibacterial agent.

Heterocyclic compound or salt thereof and intermediate thereof

Disclosed is 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one monohydrate, which has strong antibacterial activity. The compound is highly safe and useful as an original drug for pharmaceutical preparations. Also disclosed is a method which is useful for producing 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one monohydrate.

Naphthyridine derivative monohydrate and method for producing the same

Quinoxalinones as antibacterial composition

Disclosed is a compound represented by the general formula: [wherein Rrepresents an aryl or heterocyclic group which may be substituted or the like; Xrepresents a C-Calkylene group or the like; X, Xand Xindependently represent NH, a bond or the like; Xrepresents a lower alkylene group, a bond or the like; Yrepresents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z, Z, Z, Z, Zand Zindependently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z, Z, Zand Zrepresents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

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Tokyo, Japan

Fumihito Ushiyama