Nisshin Flour Milling Co., Ltd.

Fumihisa Nakata

Makoto Yanai

Shigeru Hiramoto

Norio Oshida

Noriyoshi Sueda

Nobuhiro Kinoshita

Masato Horigome

Katsutoshi Miura

Kazuhiko Yamada

Yoko Tsukada

Koichi Katsuyama

Koichi Katasuyama

Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

Urea derivatives and their use as ACAT inhibitors

Urea derivatives of formula (1) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

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Ohimachi, Japan

Fumihisa Nakata