Takara Shuzo Co., Inc.

Hokkaido University

Takara Bio Inc.

Fumihiro Higashino

Kei Fujinaga

Koichi Yoshida

[Problem] The purpose of the present invention is to provide a modified adenovirus having a cytocidal activity on a target cell and high safety. [Solution] The present invention pertains to: a modified adenovirus which comprises an E1A gene, an enhancer sequence having a function of enhancing the expression of the E1A gene, and an AU-rich element introduced into the 3′-untranslated region of a viral gene, which is essentially required for the self-propagation thereof, or a position adjacent to the 3′-untranslated region, or a modified adenovirus which comprises an E1A gene and an enhancer sequence having a function of enhancing the expression of the E1A gene and cannot express normal E4orf6 protein, wherein the distance between the 5′-terminus of the E1A gene and the terminus of the enhancer sequence is 1500-4500 bp; and a medicine comprising the same.

Modified adenovirus and medicine comprising same

Clarification of the relationship between the functions of E1AF gene and the invasion and metastasis of cancers, and application thereof to cancer control, more specifically the control of cancer cell invasion by controlling the expression of E1AF gene and the products of expression, and the detection and diagnosis of cancers by detecting the products of expression of E1aF gene.

Growing community of inventors

Sapporo, Japan

Fumihiro Higashino