Daicel Chemical Industries, Ltd.

Fumihiko Shoji

Masakazu Negawa

Hirokazu Ikeda

Akira Yamashita

In the simulated moving bed chromatographic separation process, preferably using a simulated moving bed chromatographic separation apparatus with rotary valves and/or check valves, a supercritical fluid is used as an eluent and thereby efficiency in separation and operation is remarkably improved and the concentration step after the chromatographic separation is not required.

Simulated moving bed chromatographic separation process

A process for recovering and reusing a solvent and optical isomers, characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed; recovering the solvent and the optical isomer(s) from the resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation of the optical isomers with the simulated moving bed system.

Process for recovering optical isomers and solvent process for using

A process for recovering and reusing a solvent and optical isomers, characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed: recovering the solvent and the optical isomer(s) from The resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation of the optical isomers with the simulated moving bed system.

Process for recovering optical isomers and solvent, process for using

An improved simulated moving bed separation system is disclosed. The improved novel system is characterized by being provided with rotary valves or check valves or both. The rotary valves are provided at the position where desorbing liquid is introduced, the position where the extract is taken out, the position where the feedstock is introduced and the position where the raffinate is taken out and the rotary valves are intermittently switched on and off, whereby the liquid take out of the unit packed bed preceding the position where the desorbing liquid is introduced is supplied to the circulation pump. The check valves are provided in the fluid flow passage between a unit packed bed and an extract draw-out port positioned in the next unit packed bed in the direction in the next unit packed bed in the direction of fluid flow. Thus liquid flow is smoothly controlled and the more effective separation is realized.

Simulated moving bed separation system

A process for recovering and reusing a solvent and optical isomers characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed column containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed; recovering the solvent and the optical isomer(s) from the resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation of the optical isomers with the simulated moving bed system.

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Hyogo, Japan

Fumihiko Shoji