Riken Corporation

The Jackson Laboratory

Fumihiko Ishikawa

Yoriko Saito

Osamu Ohara

Leonard D Shultz

Yasuko Koda

Hitomi Yuki

Yoshinobu Hashizume

Hiroshi Kitamura

Hidetoshi Ozawa

Atsushi Hijikata

The present invention provides a therapeutic composition for intractable leukemia comprising a drug (a) and a drug (b), wherein the drug (a) is a compound represented by the following formula (I), a salt thereof, or a prodrug thereof: wherein, Aris a substituted or unsubstituted arylene group;

Therapeutic agent for intractable leukemia

This invention relates to an agent for treating or inhibiting recurrence of acute myeloid leukemia and an agent for inhibiting growth of leukemia stem cells comprising a compound represented by formula (I) or a salt thereof: wherein Arand Areach represent aryl or heteroaryl; L represents O, S, NH, NHCO, or CONH; X represents CH or N; Y represents C-alkylene; Zrepresents hydrogen, C-alkyl, amino-C-alkyl, C-alkylamino-C-alkyl, di(C-alkyl)amino-C-alkyl, hydroxy-C-alkyl, C-alkoxy-C-alkyl, or carboxy-C-alkyl; and Zrepresents C-alkyl, amino-C-alkyl, C-alkylamino-C-alkyl, di(C-alkyl)amino-C-alkyl, hydroxy-C-alkyl, C-alkoxy-C-alkyl, or carboxy-C-alkyl, Zand Zmay, together with adjacent nitrogen, form a heterocyclic group containing as a ring member one or more hetero atoms, in addition to the nitrogen adjacent to Zand Z.

Agent for treating or inhibiting recurrence of acute myeloid leukemia

The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rgmouse by transplanting a substance containing a leukemic stem cell derived from a human acute myelogenous leukemia patient to the mouse. In addition, the invention relates to screening for a medicament capable of eradicating leukemic stem cell (LSC), consideration of treatment methods suitable for individual patients, identification of a differentially expressed gene and the like, using a mouse with expanded human leukemic cells.

Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof

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Wako, Japan

Fumihiko Ishikawa