Shin-Etsu Chemical Co., Ltd.

Fumie Tanno

Akira Yamamoto

Masaki Tanaka

Sakae Obara

Shiro Saka

Naosuke Maruyama

Kenji Yamamoto

Koichi Higuchi

Hiroyasu Kokubo

Yuichi Nishiyama

Hiroshi Umezawa

Hisashi Miyafuji

Among the conventional processes for producing solid dispersion, the solid dispersion obtained by a solvent method is excellent in terms of solubility and bioavailability of a poorly soluble drug. However, due to frequent uses of organic solvents in the solvent method, problems have arisen such as organic solvent residue in products, environmental pollution and operational safety as well as corporate problems such as capital investment and the like required to avoid such events. The present invention provides a process for preparing pharmaceutical solid preparations without use of organic solvents frequently used in conventional solvent methods. Specifically, the present invention provides a process for producing a pharmaceutical solid preparation, which is formulated by spraying a solution wherein a poorly soluble drug is dissolved in a plasticizer, and an aqueous solution and/or water dispersion of a water-soluble polymer from nozzle outlets simultaneously and separately in the process for producing the pharmaceutical solid preparation.

Process for producing a pharmaceutical solid preparation containing a poorly soluble drug

Provided are a solid preparation which rapidly disintegrates in the oral cavity when taken together with the saliva in the oral cavity or a small amount of water, can be prepared easily and has strength enough to retain its formability upon production or during distribution; and a production process of the solid preparation. Specifically, provided are a solid preparation comprising a low-substituted hydroxypropyl cellulose having a loose bulk density of 0.40 g/ml or greater and a tapped bulk density of 0.60 g/ml or greater, and a sugar and/or sugar alcohol; and a production process of the solid preparation. Also provided are a solid preparation comprising a low-substituted hydroxypropyl cellulose having a volume-average particle size as measured by the dry laser diffraction method of 25 &mgr;m or less which is obtained by pulverizing a low-substituted hydroxypropyl cellulose having a loose bulk density of 0.40 g/ml or greater, a tapped bulk density of 0.60 g/ml or greater, and a volume average particle size of 30 &mgr;m or greater&mdash;and a sugar and/or sugar alcohol; and a production process of the solid preparation.

Solid preparation containing low-substituted hydroxypropyl cellulose and production process thereof

The present invention provides a low-substituted hydroxypropyl cellulose having a loose bulk density of not less than 0.40 g/mL and a tap bulk density of not less than 0.60 g/mL and a process for producing the same.

Low-substituted hydroxypropyl cellulose and process for producing same

Solid preparation and a method of manufacturing it

An antibacterial/antifungal inorganic matter is composited with wood by impregnating wood with a solution containing a silicon alkoxide and an antibacterial/antifungal organic silicon compound having a hydrolyzable alkoxysilyl group, and subjecting the silicon compounds within the cell walls (inter- and intracellular) spaces to hydrolysis at various temperatures and polycondensation. The same is prepared by treating wood with a siloxane oligomer and curing the oligomer. The antibacterial/antifungal component is prevented from being leached out.

Method for preparing antibacterial/antifungal inorganic

Wood is modified by impregnating wood with a methylsiloxane oligomer and heating the impregnated wood to cure the oligomer. The oligomer is of the average compositional formula: (CH.sub.3 SiO.sub.3/2).sub.m (MO.sub.3/2).sub.n or [CH.sub.3 SiO.sub.3/2 ].sub.x [(CH.sub.3).sub.a SiO.sub.(4-a)/2 ].sub.y [MO .sub.3/2 ].sub.z wherein M is P, PO and/or B, m and n are positive numbers with an average ratio of m:n ranging from 99:1 to 50:50, x, y, and z are positive numbers with an average ratio of (x+y):z ranging from 99:1 to 50:50 and an average ratio of x:y ranging from 99:1 to 50:50, and a is 2 or 3, and has a hydroxyl group and/or an alkoxyl group at a terminal end. This treatment of wood is safe. Since the methylsilicone resins thus incorporated and fixed within wood are not leached out in water, the modified wood maintains flame retardance for a very long time upon exposure to rain and dew and has water repellence, decay resistance and dimensional stability.

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Niigata-ken, Japan

Fumie Tanno