Other

Nissan Chemical Industries Limited

Taisho Pharmaceutical Co., Ltd.

Fumie Sato

Tokyo Institute of Technology

Fumi Sato

Sato, Fumie

Tohru Tanami

Naoya Ono

Kazuya Kameo

Takehiro Amano

Jun Goto

Katsuaki Miyaji

Makoto Yagi

Masaru Mutoh

Kazutaka Arai

Hideo Tanaka

Hitomi Hirano

Kenji Yamada

Shigeru Okuyama

Yuuki Takayama

Toshihiro Ishii

Masamichi Fujihira

Go Ono

Misao Miyamoto

Kenichi Osawa

Iwao Arai

Norikazu Takano

Akira Hirao

Seiichi Nakahama

Hitomi c/o Taisho Pharmaceutical Co Ltd Hirano

Tohru c/o Taisho Pharmaceutical Co Ltd Tanami

Makoto c/o Taisho Pharmaceutical Co Ltd Yagi

Naoya c/o Taisho Pharmaceutical Co Ltd Ono

Hideo c/o Taisho Pharmaceutical Co Ltd Tanaka

A &#x3c0;-conjugated aromatic ring-containing compound represented by the formula (1) below is relatively stable and useful as a light-emitting material for light from blue-violet region to red region. [In the formula, R-Rindependently represent a hydrogen atom or the like; A and D independently represent a pyridine ring, pyrimidine ring, pyridazine ring, pyrazine ring, furan ring, pyrrole ring, pyrazole ring, imidazole ring, thiophene ring, benzothiadiazole ring, thieno[3,4-b]pyrazine ring, furo[3,4-b]pyrazine ring, 6H-pyrrolo[3,4-b]pyrazine ring or the like; a, aand aindependently represent 0 or 1; and nand nindependently represent an integer of 1-5.]

&#x3c0;-conjugated aromatic ring-containing compound and organic electroluminescent device

A prostaglandin derivative represented by Formula (I): wherein X is a halogen atom in the &#x3b1;- or &#x3b2;-substitution, Y is an ethylene group, a vinylene group or an ethynylene group, Ris a Ccycloalkyl group, a Ccycloalkyl group substituted with a Cstraight or branched chain alkyl group or a Ccycloalkylalkyl group, Ris a hydrogen atom or a CORgroup (Ris a hydrogen atom, a Cstraight or branched chain alkyl group or a Cstraight or branched chain alkenyl group), n is an integer of 1 to 4 and p is 0, 1 or 2,a pharmaceutically acceptable salt thereof or a hydrate thereof.

Prostaglandin derivatives

A method of treating atopy-evoked pruritic symptoms by administering a prostaglandin derivative.

Antipruritic agent

Enediyne compounds of the formula: (1) characterized in that the structure thereof is very simple and the production process is easy, and that the molecular length thereof is shorter than those of compounds having been proposed. Consequently, electrode assemblies comprising any of these enediyne compounds are highly promising in the application to nanomolecular wiring (nanomolecular wire) whose production has been difficult. 

Monomolecular conductive complex, conductive self-assembled film and assembly of electrode composed of metal and semiconductor making use of the same

A process for producing an organotitanium compound capable of regioselectively converting a substituted acetylene compound into polysubstituted benzene or polysubstituted pyridine. The process comprises reacting an acetylene compound represented by the formula (1) [where Rand Rdenote a Calkyl group or the like] in the presence of a prescribed titanium compound and a Grignard reagent with a compound represented by the formula (4) [where Rand Rdenote a hydrogen atom or the like] and further reacting with a compound represented by the formula (5) [where Rdenotes a hydrogen atom or the like, Z denotes CR' (where R&#x2032; denotes a hydrogen atom or the like), nitrogen atom, Xdenotes a halogen atom or the like, and m is 0 or 1]thereby giving the titanium compound represented by the formula (6) and/or (7). [where R&#x2dc;R, Z, X, and m are defined as above; and Xand Xdenote any of X&#x2dc;X].

Process for producing organotitanium compound and process for addition reaction

A titanium catalyst for reaction between a compound having a carbon-carbon unsaturated bond and a compound having an electrophilic functional group or an electrophilic reagent, said titanium catalyst being composed of a titanium compound represented by the formula (1) belowTiXXXX&#x2003;&#x2003;(1)(where X, X, X, and Xdenote independently a halogen atom, Calkoxyl group, aralkyloxy group, aryloxy group, or &#x2014;NRxRy group (where Rx and Ry denote independently a Calkyl group or aralkyl group), and any two of X, X, X, and Xmay form a ring.) and a Grignard reagent represented by the formula (2) below in a molar amount 1.5-2.5 times as much as the titanium compound.RMgX&#x2003;&#x2003;(2)(where Rdenotes a Calkyl group having a hydrogen atom at the &#x3b2; position and Xdenotes a halogen atom.) The titanium catalyst of the present invention activates the carbon-carbon unsaturated bond, which has a comparatively low reactivity, thereby catalyzing the reaction with an electrophilic functional group. It is inexpensive and industrially advantageous. When applied to reaction between a compound having a carbon-carbon unsaturated bond and an electrophilic functional group, it yields industrially a variety of adducts of a compound having a carbon-carbon unsaturated bond and a compound having an electrophilic functional group, and it also yields a variety of intramolecular adducts of a compound having a carbon-carbon unsaturated bond and an electrophilic functional group in the same molecule.

Titanium catalyst and organotitanium reacting reagent, production thereof, and reaction thereby

Prostaglandin E analogues

Prostaglandin E1 derivatives

Sleep inducing agent

A cis-olefin of the formula: R,&mdash;CH&boxH;CH&mdash;R,is prepared by reducing an alkyne of the formula: R,&mdash;C&equiv;C&mdash;R,with formic acid in the presence of a palladium catalyst. R,and R,are independently selected from the group consisting of a hydrogen atom, ester group, substituted silyl group, carboxyl group, cyano group, aliphatic C1-C20 hydrocarbon group, and phenyl group. The cis-olefin which is a useful intermediate for the synthesis of fine chemicals is selectively produced in high yields.

Preparation of cis&mdash;olefins

A prostaglandin derivative represented by the formula:

Prostagladin derivatives

Growing community of inventors

Fujisawa, Japan

Fumie Sato