Nof Corporation

Fumiaki Manabe

Yuji Yamamoto

Hiroki Yoshioka

A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20&#x2264;n&#x2264;2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.

Branched hetero polyethylene glycol and intermediate

Provided is a polyethylene glycol derivative which contains two PEG chains, which is bound to a diacylglycerol, which has high purity, and which enhances the stability of liposomes. Polyethylene glycol is represented by the following formula (1) and which is bound to a diacylglycerol: In Formula (1), Ris a hydrocarbon group containing 1 to 7 carbon atoms, Ris an alkyl or alkenyl group containing 9 to 21 carbon atoms, n is the average number of moles of added polyethylene glycol chains, 10&#x2266;n&#x2266;100, and X is a linker site between branched polyethylene glycol and the diacylglycerol and is represented by the following formula (2):&#x2014;(CH)-Y&#x2014;(CH)-&#x2003;&#x2003;(2)In Formula (2), Y is an ether bond, an ester bond, a urethane bond, an amide bond, or a carbonate bond and l and m are an integer of 0 to 6.

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Kawasaki, Japan

Fumiaki Manabe