Takeda Pharmaceutical Company Limited

Patcore, Inc.

Fumiaki Kikuchi

Minoru Sasaki

Keiko Kakegawa

Zenichi Ikeda

Yoichi Nishikawa

Takeshi Yamamoto

Hideyuki Sugiyama

Masahiro Ito

Takuto Kojima

Kazuaki Takami

Yasuyoshi Arikawa

Tomohiro Okawa

Masaki Daini

Yasutomi Asano

Hironobu Maezaki

Tohru Miyazaki

Ayumu Sato

Hiroshi Nara

Jinichi Yonemori

Yasuhiro Imaeda

Yuta Tanaka

Misaki Homma

Akinori Toita

Hironori Kokubo

Osamu Kubo

Masato Yoshikawa

Minoru Nakamura

Hiroki Sakamoto

Tatsuki Koike

Masaki Seto

Takeshi Ueda

Junya Shirai

Toshihiro Imaeda

Masataka Murakami

Shigekazu Sasaki

Takaharu Hirayama

Satoshi Mikami

Koichiro Fukuda

Yoshihiro Banno

Kenjiro Sato

Shinobu Sasaki

Masahiro Kamaura

Akira Kaieda

Tomohiro Ohashi

Hiromi Fukuda

Takahito Kasahara

Nao Morishita

Hirotaka Kamitani

Shiinobu Sasaki

Yuichi Horita

Toru Tanoue

Kenta Tamaki

Kazue Suzuki

Hiromasa Ishihara

Tsutomu Morita

Florian Pünner

Takeshi Yasui

The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

Heterocyclic compound

An objective of the present invention is to provide a document creation assistance server and document creation assistance method which are capable of efficiently acquiring information necessary to write a specification or other such documents, and of generating a document from the acquired information. According to an embodiment, this document creation assistance server for assisting with the creation of a document comprises: a final product identification part for accepting identification information for identifying a final product generated by synthesizing a plurality of chemical compounds; a chemical equation acquisition part for referring to electronic experiment note data which provides an electronic record of the details of an experiment relating to the synthesis of the chemical compounds, and acquiring a chemical equation for generating the final product associated with the accepted identification information; and a document generation part for generating a document including the acquired chemical equation.

Document creation assistance server and document creation assistance method

The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

HDAC6 inhibitory heterocyclic compound

A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. 

The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. Specifically, the present invention relates to a compound represented by the formula (I) or a salt thereof, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like [in the formula, each symbol is as defined in the specification].

Fused heterocyclic compound

The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification]. 

Condensed heterocyclic compound

A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein,or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.

The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

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Kanagawa, Japan

Fumiaki Kikuchi