Edmond Pharma, S.r.l.

Fulvio Gerli

Matteo Zacche'

Pier Andrea Gatti

Fabio Rondina

Pierandrea Gatti

Davide Sbarbada

The invention concerns a new, efficient process for the preparation of enantiomerically pure norepinephrine (also known as noradrenaline), or an addition salt thereof, using a catalytic hydrogenation system under hydrogen donor transfer. The invention also discloses a novel intermediate and the process for the preparation thereof.

Process for the preparation of enantiomerically pure norepinephrine

A new and efficient process to obtain Medetomidine enantiomers, a selective and potent &#x3b1;2-receptor agonist, is presented. Such process comprises a resolution step and a racemization reaction, to be able to recover the unwanted enantiomer which can be recycled as starting material.

Process for the resolution of medetomidine and recovery of the unwanted enantiomer

Disclosed is a new and efficient process for the synthesis with high yields and purity of lurasidone hydrochloride, a medicament which is useful as a psychotropic substance. The process involves the preparation of lurasidone base in a reaction system not containing inorganic salts, followed by conversion of the latter to an addition salt with an organic carboxylic acid, which is finally converted to lurasidone hydrochloride.

Growing community of inventors

Paderno Dugnano, Italy

Fulvio Gerli