Sandoz Gmbh

Sandoz Pharmaceuticals Corp.

Fulvio Gadient

Arnold Vogel

Jean-Michel Bastian

Andre Stoll

Anton Ebnother

Rudolf Suess

Adenosines derivatives of the formula ##STR1## wherein R.sub.1 is allyl, methallyl, straight or branched chain (C.sub.3-7)alkynyl, (C.sub.3-8)cycloalkyl, or phenyl mono- or independently of one another di-substituted by halogen having an atomic number of from 9 to 35, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, or CF.sub.3 ; R.sub.2 is hydrogen or C(.sub.1-4)alkyl, and R.sub.3 is (C.sub.1-4)alkyl, are useful for protecting vascular endothelium, for lowering blood lipid levels, and for treating raised blood pressure.

2'-O, N.sup.6 -disubstituted and 2'-O, N.sup.6, 2-trisubstituted

N.sup.6, 2-disubstituted or 2-substituted 1'-desoxy-1'-(6-amino-9-purinyl)-.beta.-D-ribofuranuronic acid amides, N-substituted amides, N,N-disubstituted amides, thioamides, N-substituted thioamides and N,N-disubstituted thioamides are effective against raised blood pressure.

Antihypertensive 9-(2,N.sup.6 -disubstituted adenyl) ribofuranuronic

1'-desoxy-1'-(6-amino-9-purinyl)-.beta.-D-ribofuranuronic acid thioamides of formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 possess various definitions given in claim 2, are effective against raised blood pressure.

Furanuronic acid derivatives, process for their production and their use

Diazepinoindoles or pharmaceutically acceptable acid addition salts thereof are useful as antidepressant, conflict reducing or neuroleptic agents.

Diazepinoindoles useful for treating depression, schizophrenia, social

A 1,2,3,4,5,6-hexahydro-6-phenyl-azepino[4,5-b]indole, or a pharmaceutically acceptable acid addition salt thereof is a useful neuroleptic, anti-depressant and anti-allergic agent.

1-Phenyl-azepinoindoles

2-aminoethyl-1-phenylindolines are useful as anti-diabetic and anti-obesity agents.

N-Phenylindoline derivatives, and pharmaceutical compositions containing

The present invention concerns tropane derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy,

Quaternary tropane ethers

The invention concerns novel compounds of the formula: ##STR1## wherein n is 1, 2 or 3 R.sub.1 is lower alkyl

Tricyclo piperidino ketones and soporific compositions thereof

The present invention provides compounds of formula I, ##SPC1## wherein

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Birsfelden, Switzerland

Fulvio Gadient