Sooft Italia Spa

Kemin Industries, Inc.

Offhealth S.p.a.

Fulvio Foschini

Pierre Roy

Giovanni Cavallo

Giulio Luciani

Diogo De Sousa Martins

Edoardo Stagni

Marcello Stagni

Marco Vellante

Eugenio Sodo

Alessandro Zanini

Roberto Giuva

Iontophoresis, a minimally-invasive methodology that uses a weak electric current to enhance penetration of ionized molecules into tissues, was found to be an effective technique for the intraocular delivery of large bioactive molecules, specifically lutein.

Intraocular delivery of bioactive molecules using iontophoresis

Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye; an active electrode disposed in or on the reservoir; and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body; elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery; wherein the reservoir and the active electrode are transparent to UV light and/or visible light and/or IR light. The method includes: positioning the iontophoretic device on the eye to be treated; driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA; and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW/cm; thereby obtaining the corneal cross-linking of the solution.

Device and method for corneal delivery of riboflavin by iontophoresis for the treatment of keratoconus

An improved formulation of an ophthalmic composition contains riboflavin, as cross-linking agent of corneal collagen, administered by corneal iontophoresis, able to guarantee an increased capacity of permeation of riboflavin of the corneal stroma and therefore greater therapeutic efficacy in the treatment of keratoconus.

Cross-linking composition delivered by iontophoresis, useful for the treatment of keratoconus

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Rome, Italy

Fulvio Foschini