Jilin Asymchem Laboratories Co., Ltd.

Jilin Asymchem Pharmaceuticals Co., Ltd.

Jinlin Asymchem Laboratories Co., Ltd.

Fuliang Wei

Jiangping Lu

Enxuan Zhang

Hao Hong

Sihang Yang

Guanda Che

Mingjie Feng

A preparation method for a trans-cyclobutane-o-dicarboxylic acid ester and a derivative thereof includes the following steps: in an organic solvent, catalyzing a substrate with a structure as shown in a structural formula I by using organic alkali at 50-90° C. so as to generate isomerization, acquiring the trans-cyclobutane-o-dicarboxylic acid ester or the derivative thereof, herein the structural formula I is as follows: Each R, R, Rand Ris independently one of hydrogen or an alkyl of C-C, and each of Rand Ris independently one of alkyl of C-Cand benzyl.

Preparation method for trans-cyclobutane-o-dicarboxylic acid ester and derivative thereof

Provided is a continuous synthesis method for 1,1'-bicyclic[1.1.1]pentane-1,3-diethyl ketone compounds. The continuous synthesis method comprises: under the irradiation of a light source, continuously conveying raw material A and raw material B to a continuous reaction device for a continuous photochemical reaction to obtain 1,1′-bicyclic[1.1.1]pentane-1,3-diethyl ketone compounds, and controlling the reaction temperature in the continuous reaction device by a temperature control device during the continuous photochemical reaction. A propellane with substituents, as a reaction raw material, is subjected to the above photochemical reaction in the continuous reaction device to reduce the probability of its slow decomposition and deterioration under the irradiation, and greatly improve the conversion rate of the reaction material and product yield.

Continuous synthesis method for 1, 1'-bicyclic [1.1.1]pentane-1,3-diethyl ketone compounds

Disclosed is a method for continuously synthesizing a propellane compound. The method includes the following steps: using 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane or a derivative thereof as a raw material to form a ring with a lithium metal agent by a continuous reaction, so as to synthesize the propellane compound. A technical scheme of the present disclosure is applied, and a continuous reaction device is used.

Method for continuously synthesizing propellane compound

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Tianjin, China

Fuliang Wei