Kyorin Pharmaceutical Co., Ltd.

Kyorin Seiyaku Kabushiki Kaisha

Fukutaro Taga

Mitsutomo Miyashita

Kyuya Okamura

Hiroshi Matsukubo

Toyomi Matsumoto

Haruo Sekiguchi

Katsuhiro Hamada

Toshio Maeda

Fumio Kawahara

Mitsuo Ohashi

Takashi Hirayama

N,N'-disubstituted amide derivatives

Urea derivatives of the following formula: ##STR1## wherein R.sub.2 indicates a piperidino or pyrrolidino group which may be substituted with a hydroxy group or a lower alkyl group having 1 to 13 carbon atoms; A indicates an ethylene group, propylene group, butylene group or butenylene group; R.sub.2 indicates a straight or branched alkyl group having 1 to 20 carbon atoms, a benzyl group, or a phenyl group which may have 1 to 3 substituents such as a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 3 carbon atoms, a halogen atom, a trifluoromethyl group, an amino group, a nitro group or a methylenedioxy group; and X indicates an oxygen or sulfur atom, as well as the hydrates and pharmaceutically acceptable salts thereof are useful antiulcer agents.

Urea derivatives

An ameliorating agent for dysmnesia, comprising as an effective component or components at least one of pyrazolo[1,5-a]pyridine derivatives represented by the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen or a lower alkyl of 1-4 carbons, R.sup.3 is hydrogen or a lower alkyl of 1-3 carbons or a lower alkoxy of 1-3 carbons.

Ameliorating agent for dysmnesia

Urea derivatives of the following formula, ##STR1## wherein R.sub.1 indicates a piperidino group or pyrrolidino group which may be substituted with hydroxy group or lower alkyl group having 1 to 3 carbon atoms; A indicates an ethylene group, propylene group, butylene group or butenylene group; R.sub.2 indicates a straight or branched alkyl group having 1 to 20 carbon atoms, cycloalkyl group having 3 to 6 carbon atoms, benzyl group, or phenyl group which may have 1 to 3 substituents such as lower alkyl group having 1 to 6 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, halogen atom, trifluoromethyl group, amino group, nitro group or methylenedioxy group; X indicates an oxygen or sulfur atom, the hydrates and pharmaceutically acceptable acid addition salts thereof are useful as antiulcer agents.

Anti-ulcer urea derivatives

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Shiraoka, Japan

Fukutaro Taga