American Cyanamid Company

Wyeth

American Home Products Corporation

Fuk-Wah Sum

Jay Donald Albright

Baihua Hu

Marvin Fred Reich

Aranapakam Mudumbai Venkatesan

Mark L Behnke

Katherine Lin Lee

Lihren Chen

John C McKew

James D Clark

Paresh Thakker

Michael Sotirios Malamas

Takao Abe

Atul Agarwal

Tarek Suhayl Mansour

Efren Guillermo Delos Santos

Steven Y Tam

John P Dusza

Wei Li

Xuemei Du

Steve Yikkai Tam

Efren Guillermo Santos

Yang-I Lin

Adam Matthew Gilbert

Kevin Pong

Yansong Gu

Osvaldo Dos Santos

Hideki Ushirogochi

Satoshi Tamai

Suzana Marusic

Valerie Clerin

Itsuki Yamamura

Tsuyoshi Takasaki

Ado Mihira

Jeremy Ian Levin

Lijing Chen

George Theodore Grosu

Lee Dalton Jennings

Dennis William Powell

Gerardo De Francisco

Charles V Frederick

Yixian Zhang

Scott Lee Kincaid

Steve Yik-Kai Tam

Matthew Gregory Bursavich

Charles F Howell

Yongbo Hu

John Caedmon Mckew

James Donald Clark

Mark Leo Behnke

This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition diseases and disorders including asthma, stroke, atherosclerosis, multiple sclerosis, Parkinson's disease, arthritic disorders, rheumatic disorders, central nervous system damage resulting from stroke, central nervous system damage resulting from ischemia, central nervous system damage resulting from trauma, inflammation caused or potentiated by prostaglandins, inflammation caused or potentiated by leukotrienes, inflammation caused or potentiated by platelet activation factor, pain caused or potentiated by prostaglandins, pain caused or potentiated by leukotrienes, and pain caused or potentiated by platelet activation factor.

Methods for the use of inhibitors of cytosolic phospholipase A2

The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group as defined herein; X is O; Ris H, C1-C6 alkyl, C5-C6 cycloalkyl, or CHROCOC1-C6 alkyl; and Ris hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

Bicyclic 6-alkylidene-penems as &#x3b2;-lactamase inhibitors

The present invention relates to compounds of formula I: wherein R, R, R, R, R, and Rare defined herein.

Anilino-pyrimidine analogs

This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Methods for treating asthmatic conditions

The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof, 

Tricyclic 6-alkylidene-penems as &#x3b2;-lactamase inhibitors

The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X is S.

This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase Aenzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

Methods for treating arthritic disorders

This invention provides compounds of Formula I having the structurewherein,

Cyclic amine phenyl beta-3 adrenergic receptor agonists

The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.wherein one of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is S.

A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may then be used to make other compounds, such as a compound that acts as a cPLA inhibitor.

Process for making an aldehyde

Inhibitors of cytosolic phospholipase A2

N-(4-sulfonylaryl)cyclylamine-2-hydroxyethylamines as beta-3 adrenergic receptor agonists

Cyclylamine sulfonamides as &bgr;3-adrenergic receptor agonists

N-benzhydryl indole compounds

Growing community of inventors

Pomona, NY, United States of America

Fuk-Wah Sum