Shanghai Jiao Tong University

Donghua University

Fujun Wang

Lu Wang

Jing Sun

Yimeng Li

Chaojing Li

Fan Zhao

Jihong Huang

Jifu Mao

Yaya Gao

Kun Sun

Yanan Lu

Sun Chen

Kai Bai

A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.

Preparation method of absorbable vascular stent coating for angiostenosis in infant

A stable conductive myocardial patch with a negative Poisson's ratio structure is provided. The preparation method includes preparing a myocardial patch substrate with concave polygons as the structural units by weaving or knitting, and then a conductive coating is coated on the surface of the substrate. Alternatively, the yarns can be processed into conductive coated yarns first, and then used as the raw material to weave or knit a stable conductive myocardial patch with a negative Poisson's ratio structure. The prepared myocardial patch has a relative resistance change of less than 5% at 50% tensile strain. When the strain of the structural units is within 50%, the fabric exhibits a negative Poisson's ratio structure, which expands in the perpendicular direction of the tensile load. The fabric exhibits a negative Poisson's ratio effect and anisotropy of Young's modulus, which matches the mechanical behavior of natural myocardium.

Stable conductive myocardial patch with negative Poisson's ratio structure and preparation method thereof

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Shanghai, China

Fujun Wang