Otsuka Pharmaceutical Company, Limited

Fujio Tabusa

Michiaki Tominaga

Hiroshi Shimizu

Takafumi Fujioka

Shuji Teramoto

Michinori Tanaka

Isao Takemura

Toyoki Mori

Hiroshi Yamashita

Muneaki Kurimura

Masatoshi Chihiro

Takayuki Matsuzaki

Kazuyoshi Kitano

Hisashi Nagamoto

Goro Miyakoda

Shinobu Sueyoshi

Kazuyuki Nakagawa

Hiroshi Ishikawa

Kazuyoshi Nagami

Takashi Nakagawa

Tomoichi Shinohara

Kaoru Abe

Kenji Yoshida

Kenji Nakaya

Makoto Sakamoto

Koichi Yasumura

Takumi Sumida

Shigekazu Fujita

Keizo Kan

Yutaka Kojima

Keisuke Miyajima

Tae Fukushima

Yoshihisa Tanada

Takahito Yamauchi

Masaaki Motoyama

Kazuo Sekiguchi

Hideki Takasu

Naoto Ohi

Takeshi Kodama

Masatoshi Iida

Yasuo Harada

Hironori Tsutsui

Norikazu Hashimoto

Hironori Matsuyama

The present invention provides a heterocyclic compound represented by General Formula (1):  

Heterocyclic compound and pharmaceutical composition thereof

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein Ris a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and Ris a group represented by the following general formula: (wherein R's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.

Agent for inhibition of cytokine production and agent for inhibition of cell adhesion

The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula:

Thiazole derivative

The present invention relates to novel peripheral vasodilating agents characterized by each containing as an active ingredient, a piperidine derivative or pharmaceutically acceptable salt thereof having excellent peripheral vasodilating activity. Said piperidine derivative or pharmaceutically acceptable salt thereof is represented by the general formula (1): ##STR1## (wherein R, R.sup.1 and R.sup.2 are the same as defined above.

Peripheral vasodilating agent containing piperidine derivative as active

Peripheral vasodilating agents containing as an active ingredient, a piperidine derivative or pharmaceutically acceptable salt thereof having excellent peripheral vasodilating activity, said piperidine derivative or pharmaceutically acceptable salt thereof being represented by the general formula (1) ##STR1## wherein R, R.sup.1 and R.sup.2 are as defined herein.

Peripheral vasodilators

Carbostyril derivatives or salt thereof, including novel compounds, having activities for curing and/or improving arrhythmia. Some carbostyril derivatives having similar chemical structural formula to those of carbostyril derivatives of the present invention are known in the prior art references, however, above-mentioned pharmacological activities have not been known yet.

Carbostyril derivatives and salts thereof and anti-arrhythmic agents

A piperazinylbenzoheterocyclic compound having antimicrobial properties and represented by the formula (I) ##STR1## wherein R.sup.1 represents hydrogen or lower alkyl; R.sup.2 represents hydrogen; R.sup.3 represents hydrogen, lower alkyl, lower alkanoyl, lower alkylsulfonyl, phenylalkyl, benzoyl, p-toluenesulfonyl, a group represented by the formula ##STR2## lower alkyl substituted with one to three of halogen and hydroxy, lower alkanoyl substituted with one to seven of halogen, phenylalkyl substituted with one to three of lower alkoxy on the phenyl ring, lower alkylsulfonyl substituted with one to three of halogen, lower alkenyl or lower alkynyl; R.sup.4 represents hydrogen or halogen, and n is an integer of 0 or 1, except that when n is 0, R.sup.1 and R.sup.2 together can represent the atoms necessary to form a cyclohexane ring, and when R.sup.3 represents lower alkyl substituted with one to three of halogen and hydroxy, lower alkanoyl substituted with one to seven of halogen, phenylalkyl substituted with one to three of lower alkoxy on the phenyl ring, lower alkylsulfonyl substituted with one to three of halogen, lower alkenyl or lower alkynyl, n is 1.

Piperazinylbenzoheterocyclic compounds

A .beta.-lactam series compound represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents a hydrogen atom; R.sup.3 represents a halogen atom, a nitro group, an amino group, a hydroxy group, a lower alkyl group, a lower alkoxy group, a lower alkanoylamino group, a lower alkanesulfonyloxy group or a group represented by the formula ##STR2## where R.sup.5 represents a hydrogen atom, a lower alkanoyl group, or a lower alkanesulfonyl group; R.sup.4 represents a hydrogen atom or a hydroxy group; n is 0 or 1; l is 0, 1 or 2; and A represents --C(CH.sub.3).sub.2 --CH(COOH)-- or --CH.sub.2 C(CH.sub.2 R.sup.6).dbd.C(COOH)-- where R.sup.6 represents a lower alkanoyloxy group, a group represented by the formula ##STR3## where R.sup.7 and R.sup.8 each represents a lower alkyl group and when n is 0, R.sup.1 and R.sup.2 can combine to form a cyclohexane ring together with the carbon atoms to which they are attached, and pharmaceutically acceptable salts thereof as well as a method for preparing same are disclosed. These compounds have antimicrobial activity.

.beta.-Lactam series compound and antibacterial pharmaceutical

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Tokushima, Japan

Fujio Tabusa