Mitsubishi Kasei Corporation

Mitsubishi Chemical Corporation

Fujio Suzuki

Jun Kondo

Yuji Hiraki

Yutaka Teranishi

Akihito Kamizono

Hideho Tanaka

Kazuhiro Takahashi

Akiko Mori

Ei Yamada

Atsuko Kohara

Junko Suzuki

A novel human chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF, promoting the differential potency of these cells, and inhibiting the growth of vascular endothelial cells, a DNA encoding this protein, expression vector containing the DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing the transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

Human chondromodulin-I protein

A novel chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF and promoting the differential potency of said cells, a DNA encoding said protein, expression vector containing said DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing said transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

Chondromodulin-I protein

A novel chondromodulin-II protein having a molecular weight of about 16,000 dalton on SDS-PAGE, capable of stimulating the growth of chondrocytes with or without fibroblast growth factor and promoting the differential potency of said cells, and a pharmaceutical composition containing said protein as an active ingredient.

Chondromodulin-II protein

Growing community of inventors

Toyonaka, Japan

Fujio Suzuki