Sumitomo Pharmaceuticals Company Limited

Sumitomo Chemical Company, Limited

Dianippon Sumitomo Pharma Co., Ltd.

Sumitono Pharmaceutical Company, Limited

Fujio Antoku

Kikuo Ishizumi

Hajime Kawakami

Hitoshi Fujita

Norio Fujiwara

Atsuyuki Kojima

Ikutaro Saji

Mayumi Yoshigi

Yukio Asami

Isamu Maruyama

Toshinari Sugasawa

Kiyotaka Iwai

Kukuo Ishizumi

Hiroshi Tanaka

Atuyuki Kojima

A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, Ris hydrogen, substituted or unsubstituted alkyl, etc., Ris hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Yis a direct bond, substituted or unsubstituted alkylene, &#x2014;CO(CH)&#x2014;, etc., the wavy line means (E)-configuration or (Z)-configuration, Ris substituted or unsubstituted aryl, etc., Yis substituted or unsubstituted alkylene, etc., Ris hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., Ris hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.

Five-membered cyclic compounds

1. A pyrimidine derivative of the formula (1) or a salt thereof;has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.

Bicyclic pyrimidine compounds and therapeutic use thereof

A 5-membered cyclic compound of the formula:wherein X is oxygen or sulfur, Ris hydrogen, substituted or unsubstituted alkyl, etc., Ris hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Yis a direct bond, substituted or unsubstituted alkylene, &#x2014;CO(CH)&#x2014;, etc., the wavy line means (E)-configuration or (Z)-configuration, Ris substituted or unsubstituted aryl, etc., Yis substituted or unsubstituted alkylene, etc., Ris hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., Ris hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.

Five-membered-ring compound

An imide derivative of the formula: ##STR1## or a pharmaceutically acceptable salt, which is useful as an antipsychotic drug.

Imide derivatives, and their use in pharmaceuticals

A compound of the formula: ##STR1## or its acid addition salt, which is useful as a psychotic drug.

Imide derivatives and their pharmaceutical use

A succinimide derivative of the formula: ##STR1## wherein R is a pyridyl or pyrimidinyl group substituted with at least one member selected from the group consisting of halogen, lower alkyl, lower alkoxy, cyano, benzyloxy, hydroxyl and amino, and n is an integer of 1 or 2, or a pharmaceutically acceptable acid addition salt thereof. The succinimide derivatives are useful as an anti-anxiety drugs.

Succinimide derivatives, and their production and use

Imide derivatives and their use in the treatment psychosis

A compound of the formula: ##STR1## wherein A is a carbonyl group or a sulfonyl group;

Imide derivatives and compositions for use as antipsychotic agents

A succinimide derivative of the formula: ##STR1## wherein A is straight or branched C.sub.2 -C.sub.6 alkylene or alkenylene, B is straight or branched C.sub.3 -C.sub.5 alkylene, D is straight or branched C.sub.2 -C.sub.3 alkylene, E is straight or branched C.sub.2 -C.sub.3 alkylene, R.sup.1 and R.sup.2 are each hydrogen or C.sub.1 -C.sub.4 alkyl, or they may form a single bond and R.sup.3 is a phenyl group optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: ##STR2## (in which R.sup.4 is hydrogen or phenyl), a group of the formula: CO--R.sup.5 (in which R.sup.5 is adamantyl or furyl) or hydroxy (C.sub.2 -C.sub.4) alkyl, and an acid addition salt thereof, which are useful as anti-anxiety drugs and/or anti-allergic drugs.

N-(substituted piperazinyl) alkylbicyclic succinimide derivatives

Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a broken line   is a single bond or a double bond) and Z is a hydrogen atom or, X and Z are combined to form a group of the formula: ##STR3## (wherein A and a full line are each as defined above) and Y is a hydrogen atom, R is a phenyl group, optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, a 2-pyridyl group or a 2-pyrimidinyl group and n is an integer of 3 or 4, and pharmaceutically acceptable acid addition salts thereof, which are useful as antianxious substances.

Substituted succinimides, compositions and method of use

Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a broken line ( ) is a single bond or a double bond) and Z is a hydrogen atom or, X and Z are combined to form a group of the formula: ##STR3## (wherein A and a full line are each as defined above) and Y is a hydrogen atom, R is a phenyl group, optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, a 2-pyridyl group or a 2-pyrimidinyl group and n is an integer of 3 or 4, and pharmaceutically acceptable acid addition salts thereof, which are useful as antianxious substances.

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Fujio Antoku