Advanced Cardiovascular Systems, Inc.

Abbott Cardiovascular Systems, Inc.

Fuh-Wei Tang

Syed F A Hossainy

Ni Ding

Lothar W Kleiner

Ty T Hu

Stephen D Pacetti

Syed Faiyaz Ahmed Hossainy

Syed F Hossainy

Yiwen Tang

Xiao Ma

Dorie M Happ

Yunbing Wang

Wouter Erik Roorda

Yung-Ming Chen

Shaw Ling Hsu

Brian P Cahill

Daryush Mirzaee

Orlando M Padilla

Kurt W Scheinpflug

Dorrie M Happ

Byron Lambert

Derek Mortisen

Jeff Royal

David C Gale

Timothy A Limon

Thierry Glauser

James Oberhauser

Sean A McNiven

Houdin Dehnad

Anthony S Andreacchi

Joel Harrington

Brian Riggs

Gina Zhang

Philip S Yip

Annie Liu

Mary Beth Kossuth

Andrew F McNiven

Jaya Pathak

Michael Volpone

Allen Coomber

Jean-Francois Corbett

Brandon J Yoe

Jana Buccola

A method of accelerated aging of bioresorbable polymer scaffolds including exposing the scaffold to water is disclosed. The scaffold is exposed to water at a controlled temperature for a selected aging time. The functional outputs, such as radial strength, expandability, and % recoil obtained from aged scaffolds predict those of real-time aging of the scaffold. The accelerated aging factor, which is the required shelf life divided by the aging time, is significantly higher for poly(L-lactide) scaffolds tested than thermal aging.

Accelerated aging for polymeric scaffolds

The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.

Methods of treatment of polymeric coatings for control of agent release rates

It is provided herein modified polylactide (PLA) polymers comprising biocompatibile functional group(s) on the polymers and methods of making and using the modified PLA polymers.

Modified polylactide polymers

Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.

Post electron beam conditioning of polymeric medical devices

Methods are disclosed for chemically stabilizing a polymer stent after sterilization. The stent is exposed to a temperature above ambient for a period of time after radiation sterilization. The exposure reduces the concentration of free radicals generated by the radiation.

Post electron beam stabilization of polymeric medical devices

Methods of fabricating a polymeric implantable device, such as a stent, with improved fracture toughness through annealing a polymer construct below the glass transition temperature of the polymer of the construct prior to a deformation step are disclosed herein. The deformation of the construct induces crystallization in the polymer construct through strain-induced crystallization. The annealing of the polymer construct accelerates the crystallization induced during the deformation and results in an increase in crystallite density with smaller crystallites as compared to deformation of a tube that has not been annealed. A stent scaffolding is then made from the deformed tube.

Medical device fabrication process including strain induced crystallization with enhanced crystallization

Methods of stabilizing the molecular weight of polymer stents scaffolds after E-beam sterilization are disclosed. The molecular weight of the polymer of the irradiated scaffolds is stabilized through exposure to gas containing oxygen.

Methods of stabilizing molecular weight of polymer stents after sterilization

A composite stent and a method for making the same are provided.

Composite stent with regioselective material

Methods for modulating the release rate of a drug coated stent are disclosed.

Methods for modulating the release rate of a drug-coated stent

The present invention provides an implantable medical device coating that has improved stability, a medical device coated with such coating, and a method of increasing the stability of an implantable medical device coating, wherein the coating comprises a stereocomplex f poly(D-lactic acid) and poly(L-lactice acid).

Implantable medical device coatings with improved mechanical stability

A stent mounting device and a method of coating a stent using the device are provided. The mandrel is made from or is coated with a hydrophobic or hydrophilic material, depending on the type of coating composition that is employed.

Method of coating a stent

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Temecula, CA, United States of America

Fuh-Wei Tang