Jiangsu Nuo-beta Pharmaceutical Technology Co. Ltd.

Fude Huang

Xiao Xun Zhang

Haiyan Liu

Wenan Wang

Tong Zhu

Yang He

Wanguo Wei

Lixiang Jiang

Xiao Zhang

Le Zhang

Yudong Zhou

The use of a genetic method to down-regulate RBO/EFR3/EFR3A/EFR3B proteins, TTC7 protein or PI4KIII&#x3b1; enzyme protein which interacts with RBO/EFR3/EFR3A/EFR3B proteins and TTC7 protein, or the use of a drug to inhibit PI4KIII&#x3b1; protein kinase activity reduces the accumulation of A&#x3b2;within neurons and age-dependent synaptic transmission failure and other obstacles in a fruit fly AD model, and obtains an effect of improving the learning and memory abilities of AD model mice. Provided is a method for using an RBO/EFR3/EFR3A/EFR3B inhibitor, a TTC7 inhibitor and a PI4KIII&#x3b1; inhibitor to treat Alzheimer's disease. Also provided is a method for screening a drug treating Alzheimer's disease by whether A&#x3b2; secretion by nerve cells is promoted or not.

Application of PI4KIIIA protein and related membrane protein complex in treating alzheimer's disease

Disclosed is the use of genetic means or a related inhibitor to inhibit and down-regulate the amount of PI4KIII&#x3b1; protein, RBO/EFR3/EFR3A/EFR3B membrane proteins, TTC7 protein and membrane protein complexes formed by said proteins, or related enzyme activity to promote A&#x3b2; secretion by neuronal cells, reduce A&#x3b2; accumulation within neurons, and thereby reduce AD model fruit fly and mouse nerve dysfunction.

Method for screening drug and therapeutic targets used for treating Alzheimer's disease

Growing community of inventors

Shanghai, China

Fude Huang