Schering Corporation

Opko Health, Inc.

Fucheng Zhang

George G Wu

Frank Xing Chen

Xiaoyong Fu

Marc Poirier

Minzhang Chen

Ilia A Zavialov

Michael D Green

Robert Kevin Orr

Hoa N Nguyen

Ji Xie

Ingrid Mergelsberg

Jian Cui

Cecilia A Orr

Gerald Werne

Victoria M Sprague

Liansheng Zeng

Louis Peter Castellanos

Yuyin Chen

Vilas A Dahanukar

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds

A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to synthesize Compound 7, and a coupling reaction to produce Compound 9.   

Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof

In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.

Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof

A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to synthesize Compound 7, and a coupling reaction to produce Compound 9 

In one embodiment, the present application relates to a process of making a compound of formula I:and to certain intermediate compounds that are made within the process of making the compound of formula I.

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Edison, NJ, United States of America

Fucheng Zhang