Warner-lambert Company

Fu-Zon Chung

Helen Tsenwhei Lee

Michael Huai Gu Chen

Yulong Hong

Michael Huai Chen

An assay and method for selecting analogs and derivatives of gabapentin based on the compounds inhibitory activity toward MAP kinase and MAP kinase mediated reporter gene expression. The method includes the steps of activating the MAP kinase signaling pathway, detecting the MAP kinase signal, and screening the gabapentin analogs and derivatives for inhibitory activity against the MAP kinase signal.

Vitro assay for testing gabapentinoid activity

The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, addiction disorders, inflammatory diseases, gastrointestinal disorders, vascular disorders, and neuropathological disorders.

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Ann Arbor, MI, United States of America

Fu-Zon Chung