Ciba-geigy Corporation

Ciba Vision Corporation

Novartis Ag

Novartis Pharma Gmbh

Ioltech

Fu-Pao Tsao

Stephen M Martin

Susan A Littlefield

Paul Clement Nicolson

John H Stone

Kenneth R Seamons

Larry A Alvord

Thomas Edward Rowe

Rosalind Dandridge

Harold Shlevin

George Edward Minno

Earl C McCraw, Jr

Lynn C Winterton

Barbara L Heyl

Shau Fong Yen

Karen Frances Lindley

M Alicja Sills

Earl C McCraw

Michelle P Wong

An buffered aqueous contact lens disinfecting solution having much lower concentration of disinfecting agents, and less irritating to the eye. The solutions have a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 1500 ppm. Despite having less than 1 ppm of antimicrobial, the solutions are effective againstwithin 15 minutes of contact.

Lens care composition and method

A composition for disinfecting a contact lens comprising an effective disinfecting amount of hydrogen peroxide and a surfactant comprising a copolymer of hydrophobe and hydrophile blocks the structure:HO-(hydrophobe)-(hydrophile)-(hydrophobe)-HorHO-(hydrophile)-(hydrophobe)-(hydrophile)-Hwhere x and y are integers reflecting the respective hydrophile and hydrophobe blocks of said copolymer; and the hydrophile component of the block copolymer constitutes less than 50 weight percent of the block copolymer. The block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53; 0.1%, at 50&#xb0; C.) of less than 1 mm.

Compositions and methods for cleaning contact lenses

A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.

Contact lens treating method and composition

A pharmaceutical product which includes two-chambers, one having a buffered diluent and the other having acetylcholine. Upon mixing the chamber contents, a buffered efficacious acetylcholine product is prepared for post-surgical ophthlamic injection. Another embodiment of the invention is a method of providing an acetylcholine product which has a substantially consistent final pH without substantial degradation of the acetylcholine. The method involves storing an unbuffered acetylcholine separate from a diluent solution which has been buffered, and mixing prior to use.

Methods and compositions for stabilizing acetylcholine compositions

A pH controlled protein removal system and method in the substantial absence of (a) enzyme and (b) a surfactantly effective amount of a surfactant is disclosed. The method comprises contacting a [polymeric] substrate with a cleaning composition therefor, which compostion is substantially free of (a) enzyme and (b) surfactantly effective amount of a surfactant, for a period of time at an alkaline pH and removing said substrate from said composition.

Alkaline composition for removing protein deposits

A container, composition and method for preserving treatment solutions, in which the composition includes weak and strong preservatives. The dispensing container includes media within a dispensing tip which media removes or alters the strong preservative, while allowing the weak preservative to inhibit microbial growth in the tip media. The dispensing container is especially useful in delivering to the ocular environment ophthalmic solutions which are essentially free of strong preservative which may cause patient discomfort. A dispensing container including a pH-preserved pilocarpine solution is disclosed in one embodiment.

Methods and composition for preserving media in the tip of a solution

Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound such as diethylene triamine penta(methylene phosphonic acid). These biocompatible compositions are especially useful in the ophthalmic field.

Compositions and methods for stabilizing polymers

A disinfection solution, primarily for use in conjunction with contact lenses is disclosed comprising an amount of a pharmaceutically acceptable ionic salt which is equivalent in ionic strength to at least 5% w/v sodium chloride, at least one of a C.sub.2-6 alkanol and a C.sub.3-8 alkylene glycol, a pharmaceutically acceptable surfactant, optionally a buffer, and water.

Rapid ophthalmic disinfection solution using salt and glycol and/or

A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

Method of preserving ophthalmic solution and compositions therefor

Method of preserving ophthalmic solutions and compositions therefor

Container for preserving media in the tip of a solution dispenser

A pH controlled protein removal system and method in the substantial absence of (a) enzyme and (b) a surfactantly effective amount of a surfactant is disclosed. The method comprises contacting a substrate with a cleaning composition therefor, which compostion is substantially free of (a) enzyme and (b) surfactantly effective amount of a surfactant, for a period of time at an alkaline pH and removing said substrate from said composition.

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Lawrenceville, GA, United States of America

Fu-Pao Tsao