Chinese Academy of Sciences

Fu Gao

Yan Li

Yi Shi

Mei Liu

Kun Xu

Jinghua Yan

Yaling An

Lianpan Dai

Tianyi Zheng

The embodiments of the present disclosure relate to antigens of &#x3b2;-coronaviruses, preparation methods and uses thereof. The amino acid sequence of the antigen of the &#x3b2;-coronavirus includes an amino acid sequence arranged in a (A-B)-(A-B) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B) pattern or an amino acid sequence arranged in a (A-B)-(A-B') pattern or an amino acid sequence arranged in a (A-B)-C-(A-B&#x2032;) pattern. The antigen of the &#x3b2;-coronavirus has a single-chain dimer structure. A single-chain dirtier expressed according to examples of the present disclosure is stable in content and has excellent immunogenicity as an antigen of a &#x3b2;-coronavirus, and a vaccine prepared by using the single-chain dimer as an antigen of a &#x3b2;-coronavirus can elicit high-titer neutralizing antibodies in mice.

Antigens of &#x3b2;-coronaviruses, preparation methods and uses thereof

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Beijing, China

Fu Gao