Usv Pharmaceutical Corporation

Rorer Pharmaceutical Corporation

Fu-chih Huang

Howard Jones

Bernard Loev

John T Suh

Jerry W Skiles

Wan-Kit Chan

Richard E Brown

Thomas D Lee

Joseph Auerbach

Clara Lin

Wan-kit Chan

This invention relates to chemical compounds which possess valuable therapeutic activity particularly as lipoxygenase and phospholipase C inhibitors and as platelet-activating factor receptor antagonists. The compounds posses anti-inflammatory anti-asthmatic and anti-allergic properties and are additionally useful for the treatment of myocardial infarctions. The compounds of this invention are imidazolino-containing compounds of the general formula: ##STR1##

Bis-imidazolinoamino derivatives as antiallergy compounds

There are disclosed semicarbazides having antihypertensive and angiotensin converting enzyme inhibitory activity.

Therapeutic substituted semicarbazides

This invention relates to new chemical compounds possessing valuable pharmaceutical activity, particularly as lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties.

Quinoline hydroxamates and their use as modulators of arachidonic acid

Indolyl dieneoic acids and esters are disclosed possessing valuable pharmaceutical activity, particularly as lipoxygenase inhibitors with anti-inflammatory and anti-allergic properties.

Indolyl compounds and hyposensitivity use thereof

Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

Angiotensin-converting enzyme inhibitors

##STR1## wherein Ar and Ar.sub.1 are each independently phenyl or naphthyl or a nitrogen, oxygen or sulfur-heterocyclic ring;

1-arylalkoxy- and 1-arylalkylthioaryl-2-pyrazolines as anti-inflammatory

This disclosure describes novel pharmaceutical compositions of matter which possess useful anti-inflammatory and anti-allergic properties, the active ingredients of said compositions of matter being compounds of the formula ##STR1## wherein Ar and Ar.sub.1 are each independently phenyl or naphthyl or a nitrogen, oxygen or sulfur-heterocyclic ring;

1-arylalkoxyphenyl-pyrazolines, ketones or enoles as anti-inflammatory

Provided are new compounds having valuable therapeutic activity. These compounds are of the formula: ##STR1## and salts thereof, wherein

Aryl-alkyl heterocyclic compounds

Compounds possessing valuable therapeutic activity particularly as lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties, of the formula: ##STR1## wherein Z is an unsubstituted normal alkylene chain of up to 8 carbon atoms or a substituted normal alkylene chain in which the substituent is lower alkyl, phenyl or benzyl containing up to 8 carbon atoms in the normal chain and up to a total of about 12 carbon atoms;

Antiallergic bis-imidazolinoamino derivatives

Compounds of the general formula ##STR1## and their pharmaceutically-acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

Compounds for treating hypertension

A new method of treating asthma is provided. The method is the administration of an effective dose of a Benzoxazole-2-carboxylic acid amide.

Method of treating asthma

New benzobisoxazinetetrones having anti-allergic activity are described. These benzobisoxazinetetrones are represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein: X and Y are independently O, S, NH, N-alkyl or N-aryl;

Benzobisoxazinetetrones and anti-allergic use thereof

Compounds of the formula ##STR1## and their pharmaceutically-acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

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Boonton, NJ, United States of America

Fu-chih Huang