Nycomed Imaging As

Nycomed Innovation Ab

Frode Rise

Klaes Golman

Sven Goran Andersson

Lars-Goran Wistrand

Torsten Almen

Hakan Wikstrom

Mikkel Jo Slashedrgensen

Jo Klaveness

Rolf Servin

John Varadarajan

Hangkan Wikstrom

Arne Aabye

Peter Michelsen

Arne Jo Aasen

The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging.

Use of free radicals in ESR and ESREMR imaging

Steroidal ester contrast media for x-ray and magnetic resonance imaging

The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based .pi.-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic resonance imaging (MRI), in particular electron spin resonance enhanced magnetic resonance imaging (ESREMRI). The invention also relates to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI and ESREMRI contrast media.

Use of persistent free-radicals in magnetic resonance imaging

Triarylmethyl radicals and the use of inert carbon free radicals in MRI

Use of persistent heterocyclic free-radicals in magnetic resonance

Growing community of inventors

Oslo, Norway

Frode Rise