Boehringer Mannheim Gmbh

Fritz Kaiser

Wolfgang Schaumann

Wolfgang Voigtlander

Edgar Hoyer

Kurt Stach

Klaus Koch

Peter Neubert

Kurt Stach, Deceased

Ruth Heerdt

Hans P Wolff

Hans Kuhnle

By Werner Plattner, Administrator

Wolfgang Voightlander

The present invention provides 3''-dehydrocardenolide tridigitoxoside oximes of the general formula: ##STR1## in which R.sub.1 is a hydrogen atom or an alkyl radical containing up to 3 carbon atoms, R.sub.2 is a hydrogen atom or a lower acyl or alkyl radical and R.sub.3 represents two hydrogen atoms, the group ##STR2## or the oximino group .dbd.NOR.sub.1, wherein R.sub.1 has the above-given meaning. The present invention also provides a process for the preparation of these oximes, as well as pharmaceutical compostions containing them which are useful for the treatment of cardiac insufficiency.

Oximes of 3''-dehydrocardenolide tridigitoxosides

The present invention provides ketals of 3''-dehydrocardenolide tridigitoxosides of the general formula: ##STR1## in which R.sub.1 and R.sub.2 are identical alkyl radicals containing up to 3 carbon atoms or together represent a cyclic ketal containing 2 to 6 carbon atoms, R.sub.3 represents two hydrogen atoms, the group ##STR2## or the radical ##STR3## wherein R.sub.1 and R.sub.2 have the above-given meaning, and R.sub.4 is a hydrogen atom or a lower acyl or alkyl radical. The present invention also provides processes for the preparation of these ketals, as well as pharmaceutical compositions containing them, which are useful for the treatment of cardiac insufficiency.

Ketals of 3''-dehydrocardenolide tridigitoxosides

A pyruvic acid hydrazone derivative of the formula: ##STR1## wherein R is an aryl radical optionally substituted by lower alkyl or is an aliphatic hydrocarbon radical which can be substituted by a lower alkoxy, a cycloalkyl or an optionally substituted aryl radical,

N-Substituted pyruvic acid hydrazones, preparation thereof and

Cardioactive cardenolide-bis-digitoxosides of the formula ##STR1## in which R.sub.1 is a hydrogen atom, a hydroxyl group or an acyloxy radical containing up to 3 carbon atoms, and

Cardenolide-bis-digitoxoside alkyl compounds, pharmaceutical

The present invention provides 12-dehydrodigoxin oximes of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be the same or different, are hydrogen atoms, lower acyl radicals or lower alkyl radicals or R.sub.1 and R.sub.2 together can represent an alkylidene radical containing 2 to 6 carbon atoms and R.sub.3 is a hydrogen atom or a lower alkyl or aralkyl radical. The present invention also provides a process for the preparation of these oximes and pharmaceutical compositions containing them and is also concerned with the use of these oximes for the preparation of pharmaceuticals for the treatment of cardiac insufficiency.

Cardioactive 12-dehydrodigoxin-oximes

12-Epi-digoxins of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkanoyl or alkyl radical,

Cardioactive 12-epi-digoxin and derivatives thereof

A process for the preparation of a C22-alkyl-derivative of digoxin of the formula ##SPC1## In which

Preparation of C22-alkyl derivative of digoxin

New dihydrodigoxin derivatives of the formula ##SPC1## Wherein one of R.sub.1 and R.sub.2 represents a methyl or ethyl radical and the other represents hydrogen, methyl, ethyl or acetyl (i.e. alkanoyl; and R.sub.3 is hydrogen or an acetyl group; are outstandingly effective for therapy of cardiac insufficiencies, particularly via peroral administration.

Growing community of inventors

Lampertheim, Germany

Fritz Kaiser