Bayer Aktiengesellschaft

Fritz Huper

Herbert Bartl

Bruno Bomer

Gunter Schmidt-Kastner

Erich Rauenbusch

Helmut Oberheiden

A water-soluble non-colloidal penicillinacylase preparation containing penicillinacylase covalently bound to a water-soluble carrier is produced by reacting penicillinacylase with an activated derivative of a water soluble polysaccharide in aqueous solution. The water-soluble penicillinacylase preparation efficiently hydrolyzes penicillin and permits recovery of 6-aminopenicillanic acid efficiently in extremely high purity.

Water soluble carrier-bound penicillinacylase

The reaction product from the enzymatic cleavage of amido side chains from .beta.-lactam antibiotics is purified by contact with a polymeric adsorbent.

Process for purifying products obtained from enzymatic cleavage of

There are disclosed water-insoluble proteinic preparations in which a protein or polypeptide is bound to a copolymer, which preparations are useful for binding enzymes in order to carry out enzyme-catalyzable reactions. These preparations comprise a peptide material bound to a cross-linked copolymer comprising the following copolymerized units:

Crosslinked copolymers of .alpha.,.beta.-olefinically unsaturated

There are disclosed water-insoluble proteinic preparations in which a protein or polypeptide is bound to a copolymer, which preparations are useful for binding enzymes in order to carry out enzyme-catalyzable reactions. These preparations comprise a peptide material bound to a crosslinked copolymer comprising the following copolymerized units:

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Wuppertal, Germany

Fritz Huper