Basf Aktiengesellschaft

Fritz Binnig

Manfred Raschack

Gerda Von Philipsborn

Claus D Mueller

Wilfried Lubisch

Hans P Hofmann

Horst Kreiskott

Ludwig Friedrich

Bispidine derivatives of the formula I ##STR1## where R, R.sup.1 and R.sup.3 are identical or different and are each H, C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy, when Y is ##STR2## R.sup.2 is C.sub.1 -C.sub.4 -alkyl, halogen, --CN, C.sub.1 -C.sub.4 -alkoxy, --NHSO.sub.2 CH.sub.3, --CF.sub.3, NH-acetyl or --NR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 are each C.sub.1 -C.sub.4 -alkyl, when Y is ##STR3## R.sup.2 is C.sub.1 -C.sub.4 -alkyl, halogen, --CN.sub.1 C.sub.1 -C.sub.4 -alkoxy, --NHSO.sub.2 CH.sub.3, --CF.sub.3, NH-acetyl or --NR.sup.9 R.sup.10 where R.sup.9 is C.sub.1 -C.sub.4 -alkyl and R.sup.10 is H or C.sub.1 -C.sub.4 -alkyl, and when X is not CH.sub.2 R.sub.2 may also be NO.sub.2 or NH.sub.2, X is --CH.sub.2 --, --C(O)-- or --C(R.sup.6)OR.sup.7 -- (where R.sup.6 is H or C.sub.1 -C.sub.4 -alkyl and R.sup.7 is H, C.sub.1 -C.sub.4 -alkyl or ##STR4## where R.sup.8 is H, C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy), Y is --C(O) or --CONH-- and Z is C.sub.1 -C.sub.4 -alkylene which may be olefinically unsaturated and/or branched, and their physiologically tolerated salts, and drugs containing these compounds as active compounds are described.

Bispidine derivatives as class III antiarrhythmic agents

Bispidine derivatives of the formula I ##STR1## where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

Bispidine derivatives and antiarrhythmic compositions

Bispidine derivatives of the formula I ##STR1## where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds possess antiarrhythmic properties.

Method of treating cardiac disorders using bispidine derivatives

Bispidine derivatives of the formula ##STR1## where R.sup.1 is H or C.sub.6 H.sub.5, R.sup.2 is H, Cl or CF.sub.3, R.sup.3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.

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Fritz Binnig