Cardiac Pacemakers, Inc.

Medtronic, Inc.

Universiteit Maastricht

Academisch Ziekenhuis Maastricht

St. Anne's University Hospital Brno

Institute of Scientific Instruments of the Czech Academy of Sciences, V. V. I.

Charles University

Cardian S.r.o.

University Maastricht

Frits W Prinzen

Richard N Cornelussen

Joseph M Pastore

Ward Y R Vanagt

Tamara Colette Baynham

Julio Cesar Spinelli

Andrew P Kramer

Allan Charles Shuros

Jihong Qu

Ward Y Vanagt

Alfonso Aranda Hernandez

Elien B Engels

Jeffrey M Gillberg

Pierre Andre Grandjean

Pavel Leinveber

Pavel Jurak

Miroslav Novak

Josef Halamek

Vlastimil Vondra

Ivo Viscor

Jolana Lipoldova

Alexander Adrianus Martinus Verbeek

Filip Piesinger

Radovan Smisek

Magdalena Matejkova

Kevin Vernooy

Karol Curila

Jana Vesela

Ivo Nekuda

Vit Nekuda

Chester W Struble

Eilen B Engels

Ward YR Vanagt

A method of processing of electrocardiogram includes the steps of providing an electrocardiogram comprising signals in at least two channels; selecting at least two frequency ranges of the signal in each of the said at least two channels; calculating an envelope for the signal in each frequency range in each channel; dividing the calculated envelope of the signal in each frequency range in each channel into QRS complex segment envelopes; and computing an average or median envelope as an average or mean of QRS complex segment envelopes for each frequency range in each channel.

Method of electrocardiographic signal processing and apparatus for performing the method

A system for use during revascularization includes a catheter having an adjustable balloon for delivery a stent, one or more pacing electrodes for delivering one or more pacing pulses to a patient's heart, and a pacemaker configured to generate the one or more pacing pulses to be delivered to the heart via the one or more pacing electrodes. The one or more pacing pulses are delivered at a rate substantially higher than the patient's intrinsic heart rate without being synchronized to the patient's intrinsic cardiac contractions, and are delivered before, during, or after an ischemic event to prevent or reduce cardiac injury.

Method and apparatus for pacing during revascularization

In some examples, controlling delivery of CRT includes delivering ventricular pacing according to a sequence of different values of at least one of A-V delay or V-V delay, and acquiring one or more electrograms from respective vectors. For each of the different values of the at least one of A-V delay or V-V delay, at least one of a QRS amplitude or a QRS area may be determined based on the one or more electrograms, and a target change in QRS amplitude or QRS area between adjacent ones of the values of the at least one of A-V delay or V-V delay of the sequence may be identified. In response to the identification of the target change, the implantable medical device may deliver the ventricular pacing at a value of the at least one of A-V delay or V-V delay determined based on the identification to provide CRT.

Electrogram-based control of cardiac resynchronization therapy

A cardiac resynchronization pacemaker and a method of adjusting the pacemaker. The method includes deriving a vectorcardiogram from implanted electrodes (D-VCG), analyzing the D-VCG, deriving optimal CRT pacing parameters from the analysis of the D-VCG, and adjusting the CRT pacemaker according to the derived parameters. The pacemaker may include a processor configured to perform the method.

Method and apparatus for optimization of cardiac resynchronization therapy using vectorcardiograms derived from implanted electrodes

Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.

A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.

Method and apparatus for initiating and delivering cardiac protection pacing

A method for pacing a left ventricle of a heart includes delivering a pacing pulse via a first electrode to activate a first papillary muscle and another pacing pulse via a second electrode to activate a second papillary muscle.

Papillary muscle stimulation

A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.

Intermittent stress augmentation pacing for cardioprotective effect

A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.

Growing community of inventors

Maastricht, Netherlands

Frits W Prinzen