Abbott Laboratories Corporation

Stichting Voor De Technische Wetenschappen

Perimed Ab

Frits Frans Maria De Mul

Omar S Khalil

Johannes Sake Kanger

Charles F Hanna

Shu-jen Yeh

Xiaomao Wu

Wiendelt Steenbergen

Rene&prime; Alexander Bolt

Jan Greve

Alexander Nikolaevich Serov

Rene' Alexander Bolt

Laser Doppler Perfusion Imaging system including a laser light source (), an image detector (), and signal detector (); the laser light source (), in use, being arranged for illuminating a selected area of interest () on a sample () for determining perfusion related data of the sample (), the image detector, in use, being arranged for capturing an image of the sample (), and the signal detector (), in use, being arranged for detecting a laser Doppler signal from the selected area of interest () on the sample (), wherein the laser light source () comprises optical means () for creating a laser beam comprising a plurality of beams.

Laser doppler perfusion imaging with a plurality of beams

Method for non-invasively determining the concentration of an analyte by compensating for the effect of tissue hydration

Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e.g., stratum corneum and epidermis, in these determinations.

Non-invasive sensor capable of determining optical parameters in a sample having multiple layers

Apparatus and method for non-invasively measuring at least one optical parameter of a sample, particularly a sample of tissue that comprises a plurality of layers. The at least one parameter can be used to determine the presence or concentration of an analyte of interest in the sample of tissue. The apparatus and method of the present invention (1) measure light that is substantially reflected, scattered, absorbed, or emitted from a shallower layer of the sample of tissue, (2) measure light that is substantially reflected, scattered, absorbed, or emitted from a deeper layer of the sample of tissue, (3) determine at least one optical parameter for each of these layers, and (4) account for the effect of the shallower layer on the at least one optical parameter of the deeper layer. Specifying the sampling depth allows determinations of the optical properties of a specific layer of the sample of the tissue, e.g., dermis, and decreases interference from other layers, e. g., stratum corneum and epidermis, in these determinations.

The invention relates to an optical phantom that is suitable for simulating the optical properties of biological material and to a method of producing said phantom. The phantom is comprised of a matrix of poly(vinyl alcohol) (PVA) and spherical particles whose refractive index differs from that of the PVA. Preferably the PVA has a level of hydrolysis of >98%. Preferably the spherical particles are hollow polystyrene particles. In addition, light-absorbing and light-scattering substances may be added to the matrix.

Optical phantom suitable for stimulating the optical properties of biological material and a method of producing said phantom

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Almelo, Netherlands

Frits Frans Maria De Mul